LACTAM

作品数：46被引量：54H指数：4
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Amide-Based Morita–Baylis–Hillman Carbonates for Phosphine-Catalyzed Asymmetric(4+2)Annulation
《Chinese Journal of Chemistry》2024年第24期3269-3277,共9页Min Liu Qihuan Han Lan Wang Xi Chen Xue Zhang Hongchao Guo 
supported by the National Natural Science Foundation of China(Nos.21871293,22071264).
Chiral phosphine-catalyzed asymmetric(4+2)annulation of the amide-based Morita–Baylis–Hillman(MBH)carbonates withβ,γ-unsaturated butenolides has been developed to give enantiomer-enriched bicyclicδ-lactamγ-butyr...
关键词：Asymmetric catalysis Asymmetric synthesis Phosphine catalysis Organocatalysis Cycloaddition ANNULATION AMIDE MBH carbonate LACTAM Piperidinone Heterocycle 
Ni–Al Bimetal-Catalyzed Tertiary C(sp^(3))–H Activation for Dual C–H Annulation of Formamides with Alkynes
《CCS Chemistry》2024年第11期2671-2678,共8页Yi Li Yu-Peng Liu Mengying Xu Weiwei Xu Feng-Ping Zhang Mengchun Ye 
the National Key R&D Program of China(grant no.2022YFA1504300);the National Natural Science Foundation of China(grant nos.22188101 and 22325103);the Haihe Laboratory of Sustainable Chemical Transformations and“Frontiers Science Center for New Organic Matter,”Nankai University(grant no.63181206);the Fundamental Research Funds for the Central Universities for financial support.
3d-Metal-catalyzed tertiary C(sp^(3))–H bond activation has been a formidable challenge.Herein,a tertiary C(sp^(3))–H bond is smoothly activated by Ni–Al bimetallic catalysts for dual C–H annulation of formamides ...
关键词：tertiary C(sp3)–H bond activation dual C–H annulation LACTAM BIMETAL nickel 
Intramolecularly lactam stapled oxyntomodulin analogues inhibit cancer cell proliferation in vitro
《Chinese Chemical Letters》2023年第4期222-225,共4页Junli Wang Cen Liu Hongliu Yang Tao Ma Yonggang Liu Fener Chen 
As a glucagon(GCG) receptor(GCGR) and glucagon-like peptide 1(GLP-1) receptor(GLP-1R) dual agonist, oxyntomodulin(OXM) has been attracting scientific attentions due to its efficacies of suppressing appetite, increasin...
关键词：Oxyntomodulin analogues Intramolecular lactam Dual GCGR/GLP-1R activations Anti-PANC-1 proliferation 
Enantioselective Synthesis ofα-Alkenylatedγ-Lactam Enabled by Ni-Catalyzed 1,4-Arylcarbamoylation of 1,3-Dienes被引量：2
《CCS Chemistry》2023年第2期341-349,共9页Feng He Liting Hou Xianqing Wu Haojie Ding Jingping Qu Yifeng Chen 
supported by National Natural Science Foundation of China(grant no.22171079);the Natural Science Foundation of Shanghai(grant no.21ZR1480400);the Shanghai Rising-Star Program(grant no.20QA1402300);the Shanghai Municipal Science and Technology Major Project(grant no.2018SHZDZX03);the Program of Introducing Talents of Discipline to Universities(grant no.B16017);the Fundamental Research Funds for the Central Universities and the China Postdoctoral Science Foundation(grant no.2021M701197).
The facile construction of chiral quaternaryα-alkenylated pyrrolidinones is a long-term challenge in organic synthesis.The asymmetric difunctionalization of 1,3-dienes represents the most compelling tool for assembli...
关键词：LACTAM NICKEL 1 3-diene enantioselective dicarbofunctionalization quaternary stereogenic center 
pH-activatable lactam-stapled peptide-based nanoassemblies for enhanced chemo-photothermal therapy被引量：1
《Nano Research》2022年第9期8315-8325,共11页Yao Xiao Ling Zhang Mengzhen Shi Rui Tang Zherui Jiang Yue Song Yuan Tian Shaobing Zhou 
the National Key Research and Development(R&D)Program of China(No.2021YFB3800900);the Natural Science Foundation of China(Nos.51725303,21708031,and 52033007);the National Postdoctoral Program for Innovative Talents(No.BX20180264);China Postdoctoral Science Foundation(No.2018M643519);the Sichuan Science and Technology Program(No.2020JDRC0051);the Fundamental Research Funds for the Central Universities(No.2682021ZTPY075)。
The practical application of nanomedicines for cancer therapy is generally hampered by their compromised tumor accumulation and transmembrane potency.Cell penetrating peptides(CPPs)have been widely used to enhance the...
关键词：lactam-stapled peptide PH-RESPONSIVE NANOASSEMBLIES CHEMOTHERAPY photothermal therapy 
Steric-switched defluorofunctionalization selectivity: controlled synthesis of monofluoroalkene-masked medium-sized heterocyclic lactams and lactones
《Science China Chemistry》2022年第3期554-562,共9页Hao Zeng Hengyuan Li Huanfeng Jiang Chuanle Zhu 
supported by the National Natural Science Foundation of China (21702064);the Guangdong Basic and Applied Basic Research Foundation (2020B1515020012)。
The steric-switched ipso-defluoroamination-triggered and ipso-defluorooxylation-triggered cyclization of(trifluoromethyl)alkenes with amino alcohols and diamines are achieved under mild conditions. This regioselective...
关键词：switched-selectivity C–F bond cleavage medium-sized heterocycle LACTAM lactone 
Use of a Removable Backbone Modification Strategy to Prevent Aspartimide Formation in the Synthesis of Asp Lactam Cyclic Peptides
《Chinese Journal of Chemistry》2021年第9期2517-2522,共6页Tingting Cui Junyou Chen Rui Zhao Yanyan Guo JiahuiTang Yulei Li Yi-Ming Li Donald Bierer Lei Liu 
supported by the National Key R&D Program of China(No.2017YFA0505200);the National Natural Science Foundation of China(Nos.91753205,21877024,21621003,81621002);the Fundamental Research Funds for the Central Universities(No.JZ2019HGPB0105).
The synthesis of an Asp lactam derivative of A-183,a selective inhibitor of Factor 7a with good anticoagulant and antithrombotic activity,is described.Our synthesis depends on the use of a removable backbone modificat...
关键词：PEPTIDES Solid-phase synthesis Synthetic methods Aspartimide Lactam cyclic peptides 
Electrochemical Ring Expansion to Synthesize Medium-Sized Lactams Through C–C Bond Cleavage
《CCS Chemistry》2021年第8期2236-2247,共12页Kun Liu Chunlan Song Xu Jiang Xin Dong Yuqi Deng Wenxu Song Yanpei Yang Aiwen Lei 
the National Natural Science Foundation of China(no.21520102003);the Hubei Province Natural Science Foundation of China(no.2017CFA010);the Program of Introducing Talents of Discipline to Universities of China(111 Program)for their generous financial support.
Medium-sized nitrogen heterocycles are prevalent motifs in many kinds of bioactive molecules and natural products.Owing to the unfavorable enthalpic and entropic barriers during the transition states,access to medium-...
关键词：ELECTROCHEMISTRY medium-sized lactam ring expansion C–C bond cleavage nitrogen radical 
Ruthenium(Ⅱ)-cored supramolecular organic framework-mediated recyclable visible light photoreduction of azides to amines and cascade formation of lactams被引量：3
《Chinese Chemical Letters》2019年第7期1383-1386,共4页Yi-Peng Wu Meng Yan Zhong-Zheng Gao Jun-Li Hou Hui Wang Dan-Wei Zhang Junliang Zhang Zhan-Ting Li 
supported by the National Natural Science Foundation of China (Nos. 21432004 and 21890732)
Ru(bpy)3]2+-cored supramolecular organic framework SMOF-1, assembled from a [Ru(bpy)3]2+-derived hexaarmed molecule and cucurbit[8]uril, has been demonstrated to heterogeneously catalyze visible light-induced reductio...
关键词：SUPRAMOLECULAR organic framework Visible light photocatalysis RECYCLABILITY AZIDE reduction Amine LACTAM 
Bis‐Lactam Peptide [i, i + 4]‐Stapling被引量：1
《Chinese Journal of Chemistry》2019年第3期244-248,共5页Xiao Hu Bo Wu Weiping Zheng 
Summary of main observation and conclusion Even though the bis‐lactam peptide stapling with the [i, i + 7] and the [i, i + 11] systems has been known to be able to afford %α‐helicity values up to 100%(25°C), the p...
关键词：BIS BIS HAS be our was can 
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