Structural identification and antioxidative activity evaluation of flaxseed lignan macromolecules: structure-activity correlation  

作　　者：Chen Cheng Lei Wang Xiao Yu Fenghong Huang Jing Yang Fang Geng Xiaoyang Xia Xia Xiang Shufang Xu Qianchun Deng 

机构地区：[1]Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences,Oil Crops and Lipids Process Technology National&Local Joint Engineering Laboratory,Hubei Key Laboratory of Lipid Chemistry and Nutrition,and Key Laboratory of Oilseeds Processing,Ministry of Agriculture and Rural Affairs,Wuhan 430062,China [2]College of Food and Bioengineering,Zhengzhou University of Light Industry,Zhengzhou 450002,China [3]Key Laboratory of Coarse Cereal Processing(Ministry of Agriculture and Rural Affairs),School of Food and Biological Engineering,Chengdu University,Chengdu 610106,China [4]Clinical Nutrition Department,the Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430014,China

出　　处：《Food Science and Human Wellness》2024年第6期3224-3235,共12页食品科学与人类健康（英文）

基　　金：support from National Natural Science Foundation of China(32072267);supported by China Agriculture Research System of CRAS-14.

摘　　要：Flaxseed lignan macromolecules(FLM)are a class of important secondary metabolites in fl axseed,which have been widely concerned due to their biological and pharmacological properties,especially for their antioxidative activity.For the composition and structure of FLM,our results confirmed that ferulic acid glycoside(FerAG)was directly ester-linked with herbacetin diglucoside(HDG)or pinoresinol diglucoside(PDG),which might determine the beginning of FLM biosynthesis.Additionally,p-coumaric acid glycoside(CouAG)might determine the end of chain extension during FLM synthesis in fl axseed.FLM exhibited higher antioxidative activity in polar systems,as shown by its superior 1,1-diphenyl-2-picrylhydrazyl(DPPH)free radical scavenging capacity compared to the 2,2’-azinobis(3-ehtylbenzothiazolin-6-sulfnic acid)(ABTS)cation free radical scavenging capacity in non-polar systems.Moreover,the antioxidative activity of FLM was found to be highly dependent on its composition and structure.In particular,it was positively correlated with the number of phenolic hydroxyl groups(longer FLM chains)and inversely related to the steric hindrance at the ends(lower levels of FerAG and CouAG).These fi ndings verifi ed the potential application of FLM in nonpolar systems,particularly in functional food emulsions。

关 键 词：Flaxseed lignan macromolecules Composition structure Antioxidative activity STRUCTURE-ACTIVITY Correlation Flaxseed lignan macromolecules Composition structure Antioxidative activity STRUCTURE-ACTIVITY CORRELATION 

分 类 号：TS201.2[轻工技术与工程—食品科学]