Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study  

作　　者：Mirco Vacca Eduardo Maria Sommella Marina Liso Giulio Verna Aurelia Scarano Annamaria Sila Margherita Curlo Mauro Mastronardi Katia Petroni Chiara Tonelli Bruno Di Jeso Angelo Santino Vincenzo Vestuto Fabrizio Merciai Gianluigi Giannelli Pietro Campiglia Maria De Angelis Marcello Chieppa Francesco Maria Calabrese 

机构地区：[1]Department of Soil,Plant and Food Science,University of Bari Aldo Moro,Bari 70126,Italy [2]Department of Pharmacy,School of Pharmacy,University of Salerno,Fisciano 84084,Italy [3]Functional Gastrointestinal Disorders Research Group,National Institute of Gastroenterology IRCCS“S.de Bellis”,Castellana Grotte 70013,Italy [4]Department of Medicine,Digestive Health Research Institute,Case Western Reserve University School of Medicine,Cleveland 44106,USA [5]Unit of Lecce,Institute of Sciences of Food Production C.N.R.,Lecce 73100,Italy [6]Department of Biosciences,University of Milan,Milan 20133,Italy [7]Department of Biological and Environmental Sciences and Technologies,University of Salento,Lecce 73100,Italy [8]Department of Biological and Environmental Sciences and Technologies(DISTEBA),University of Salento,Lecce 73100,Italy

出　　处：《Food Science and Human Wellness》2024年第6期3536-3543,共8页食品科学与人类健康（英文）

基　　金：supported by the grant from Italian Ministry of Health Ricerca Corrente 2023 IRCCS“S.de Bellis”;by the Apulia Region grant SiCURA“Soluzioni Innovative per la gestione del paziente e il follow up terapeutico della Colite UlceRosA”(KC3U5Y1).

摘　　要：Nowadays,inflammatory bowel disease(IBD)-patient therapies are mainly based on corticosteroid,thiopurine,and immunomodulator treatments.Patients with active disease,that do not respond to corticosteroid and/or thiopurine treatment,can switch to the usage of the chimeric monoclonal antibody infliximab(IFX).However,to date,no treatment appeared to be conclusive in lowering the incidence of IBD relapses.With the aim to increase the effectiveness of IFX treatment,we combined it with an adjuvant purple corn supplementation enriched in anthocyanins.IBD-patients were enrolled before they underwent to the IFX-infusion,and they were allocated in 2 different study arms.Patients in the intervention-arm followed a dietary supplementation with purple corn water-soluble extract,whereas control patients had a daily consumption of red fruit tea.16S rDNA gene-sequencing and high-resolution mass-spectrometry metabo-lipidomics analyses were conducted on stool and sera samples,respectively.As a result,the experimental intervention mainly affected the serum metabolome of IBD-patients by decreasing the concentration of specific lipids.Focusing on IBD patient annotated taxa,a significant decrease in Lactobacillus and Bifi dobacterium relative abundances was found.As far as it concerns the ulcerative colitis patient subset,the experimental intervention led to a decrease in Alistipes and Erysipelotrichaceae UCG-003 genus abundances and a concomitant Parabacteroides increase.On the contrary,after treatment,Crohn’s disease patients did not exhibit metataxonomics differences at the genus level.At the end of the treatment that led to a reshaped microbiota community,the gathered data paves the way for the usage of a specifically designed probiotic supplementation as a valuable strategy for IBD-patients under IFX infusion.

关 键 词：Inflammatory bowel disease infliximab infusion ANTIOXIDANTS NUTRIGENOMICS Adjuvant therapy 

分 类 号：R574[医药卫生—消化系统] TS201.4[医药卫生—内科学]