放疗后肌肉纤维化的发病机制及康复治疗策略研究进展  

Research progress on the pathogenesis and rehabilitation strategies of radiation-induced muscle fibrosis

作　　者：黎芸 刘夕霞[2,3] Li Yun;Liu Xixia(Guangxi University of Chinese Medicine,Nanning 530219,China;Joint Training Base of Guangxi University of Chinese Medical,Department of Rehabilitation,People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;Guangxi Academy of Medical Sciences,Nanning 530021,China)

机构地区：[1]广西中医药大学,南宁530219 [2]广西壮族自治区人民医院康复医学科,广西中医药大学联合培养基地,南宁530021 [3]广西医学科学院,南宁530021

出　　处：《中华放射医学与防护杂志》2024年第11期985-990,共6页Chinese Journal of Radiological Medicine and Protection

基　　金：广西自然科学基金项目(2023GXNSFAA026175)。

摘　　要：放射性纤维化(RIF),尤其是放射治疗引起的肌肉纤维化(RIMF),是一种常见的放疗相关并发症。放疗后随着时间推移,患者肌肉僵硬及关节活动障碍逐渐加重,严重影响癌症患者的生活质量。本综述旨在探讨放疗后肌肉纤维化的发生机制、诊断与评估方法,以及其康复治疗手段的最新研究进展,为放疗后肌肉纤维化的患者提供系统、有效的健康管理和康复治疗策略,改善患者预后。Radiation-induced fibrosis,especially radiation-induced muscle fibrosis(RIMF),is a common complication associated with radiotherapy.After radiotherapy,there is a gradual worsening of muscle stiffness and joint mobility impairments over time,which severely affects the quality of life of cancer patients.This article aims to review the latest research progress on the mechanisms and diagnosis and assessment methods of RIMF,as well as its rehabilitation strategies.This review provides systematic and effective health management and rehabilitation strategies to improve the prognosis of patients with RIMF.

关 键 词：放疗后肌纤维化 转化生长因子Β 结缔组织生长因子 肿瘤相关成纤维细胞 康复治疗策略 

分 类 号：R730.55[医药卫生—肿瘤]