Naringin and Naringenin:Potential Multi-Target Agents for Alzheimer’s Disease  

作　　者：Jing LU Jie CHEN Shu-yue LI Guang-jie PAN Yi OU Li-fu YUAN Jian-ping JIANG Ling-hui ZENG Jie ZHAO 

机构地区：[1]Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province,School of Medicine,Hangzhou City University,Hangzhou,310015,China [2]College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou,310015,China [3]Affiliated Hospital,Hangzhou City University School of Medicine,Hangzhou,310015,China

出　　处：《Current Medical Science》2024年第5期867-882,共16页当代医学科学（英文）

基　　金：supported by the Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(No.TGD23C050001);by National Natural Science Foundation of China(No.82074186).

摘　　要：Alzheimer’s disease(AD)is one of the most common forms of neurodegenerative dementia.The etiology of AD is multifactorial,and its complex pathophysiology involves tau and amyloid-βdeposition,increased oxidative stress,neuroinflammation,metabolic disorders,and massive neuronal loss.Due to its complex pathology,no effective cure for AD has been found to date.Therefore,there is an unmet clinical need for the development of new drugs against AD.Natural products are known to be good sources of compounds with pharmacological activity and have potential for the development of new therapeutic agents.Naringin,a naturally occurring flavanone glycoside,is predominantly found in citrus fruits and Chinese medicinal herbs.Mounting evidence shows that naringin and its aglycone,naringenin,have direct neuroprotective effects on AD,such as anti-amyloidogenic,antioxidant,anti-acetylcholinesterase,and anti-neuroinflammatory effects,as well as metal chelation.Furthermore,they are known to improve disordered glucose/lipid metabolism,which is a high risk factor for AD.In this review,we summarize the latest data on the impact of naringin and naringenin on the molecular mechanisms involved in AD pathophysiology.Additionally,we provide an overview of the current clinical applications of naringin and naringenin.The novel delivery systems for naringin and naringenin,which can address their widespread pharmacokinetic limitations,are also discussed.The literature indicates that naringin and naringenin could be multilevel,multitargeted,and multifaceted for preventing and treating AD.

关 键 词：Alzheimer’s disease NARINGIN NARINGENIN multitarget 

分 类 号：O62[理学—有机化学]