脑深部电刺激:难治性精神障碍的机遇与挑战  

Deep brain stimulation:Opportunities and challenges for treatment-resistant psychiatric disorders

作　　者：刘登堂[1,2] 翟兆琳 路畅 徐一峰[1] 江开达[1] LIU Dengtang;ZHAI Zhaolin;LU Chang;XU Yifeng;JIANG Kaida(Shanghai Mental Health Center,Shanghai 200030,China;Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China)

机构地区：[1]上海市精神卫生中心,上海200030 [2]复旦大学附属华山医院

出　　处：《中国神经精神疾病杂志》2024年第10期577-579,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：作为一项新型神经调控技术,脑深部电刺激(deep brain stimulation,DBS)在难治性精神障碍领域的应用近年来受到广泛关注。基于当下的研究前沿,本述评提出DBS在精神疾病方面具有独特性和前瞻性的问题,包括治疗靶点、刺激模式、闭环调控、长期疗效等,对未来的研究方向提出建议与展望。As a novel neuromodulation technology,the application of deep brain stimulation(DBS)in treatment resistant psychiatric disorders has received widespread attention in recent years.Based on the current research frontiers,this review puts forward several unique and insightful issues of DBS in psychiatric disorders,including therapeutic targets,stimulation modes,closed-loop modulation,and long-term efficacy in order to provide suggestions and perspectives for future research directions.

关 键 词：难治性精神障碍 脑深部电刺激 脑机接口 闭环神经调控 神经可塑性 

分 类 号：R749[医药卫生—神经病学与精神病学]