基于自动纤维定量技术研究卒中后抑郁的纤维束改变  

Study on microstructural changes in white matter fibers of patients with post stroke depression based on automated fiber quantification

作　　者：卢秋红[1,2] 黄燕兰[1] 刘婕 王淼[1] 梁志坚[1] 陆顺祖 LU Qiuhong;HUANG Yanlan;LIU Jie;WANG Miao;LIANG Zhijian;LU Shunzu(Department of Neurology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院神经内科,南宁530021 [2]广西医科大学第一附属医院心理卫生科 [3]广西医科大学第一附属医院放射科

出　　处：《中国神经精神疾病杂志》2024年第10期586-591,共6页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金地区项目(编号:82260243);广西自然科学基金青年基金项目(编号:2022GXNSFBA035501);广西卫生健康委员会自筹课题(编号:Z20210864)。

摘　　要：目的通过自动纤维定量(automated fiber quantification,AFQ)技术研究卒中后抑郁(post-stroke depression,PSD)神经纤维束的结构改变,并探索与抑郁程度相关的纤维节段。方法纳入单部位前循环脑梗死患者,分为PSD组和卒中后非抑郁(non-PSD)组,收集发病1个月时的汉密尔顿抑郁量表(Hamilton depression scale,HAMD)和MRI数据,采用AFQ提取神经纤维束节段的部分各项异性(fractional anisotropy,FA),评估纤维束节段FA组间差异,以及差异纤维束节段FA与HAMD的相关性。结果共收集8例PSD和18例non-PSD患者。与non-PSD组相比,PSD组胼胝体、左侧下纵束和钩状束的节段FA降低(P<0.05)。所有患者胼胝体小钳(r=-0.418,P=0.047)和左侧钩状束(r=-0.467,P=0.029)部分节段FA与其HAMD呈负相关。结论AFQ精确地揭示了PSD患者的神经纤维束存在节段性的微结构损害,且胼胝体小钳和钩状束节段性微结构损害与抑郁严重程度有关。Objective To explore the microstructural changes in white matter(WM)fibers of patients with post-stroke depression(PSD)by using automated fiber quantification(AFQ)and the relationship between changes in fibers and the Hamilton depression scale(HAMD).Methods The HAMD and MRI data were collected from stroke patients with a single anterior circulation infarction at 1-month follow-up.AFQ was used to extract the main fibers and calculate the fractional anisotropy(FA)of each node in each fiber.The difference of node FA in each fiber between groups and correlations between altered node FA and HAMD were then evaluated.Results Data were collected from 8 patients with PSD and 18 patients without PSD(non-PSD).Compared with that in non-PSD,the node FA in the callosum,left inferior longitudinal fasciculus,and uncinate fasciculus were significantly decreased in patients with PSD(P<0.05).The altered node FA values in the corpus callosum forceps minor(r=-0.418,P=0.047)and left uncinate fasciculus(r=-0.467,P=0.029)were negatively related to HAMD in patients with PSD.Conclusions AFQ can precisely measure the segmental microstructural damage of nerve fiber bundles in patients with PSD,of which segmental microstructural damage of the corpus callosum forceps and hook tracts is associated with the severity of depression.

关 键 词：卒中后抑郁 缺血性脑卒中 结构损害 自动纤维定量 弥散张量成像 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]