多学科综合治疗新模式下口腔癌放射治疗的进展与挑战  

Progress and challenges of radiotherapy for oral cancer under the new mode of multidisciplinary treatment

作　　者：李麟 王静波(综述) 易俊林(审校) Lin Li;Jingbo Wang;Junlin Yi(Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科,北京市100021

出　　处：《中国肿瘤临床》2024年第19期980-987,共8页Chinese Journal of Clinical Oncology

基　　金：中国癌症基金会北京希望马拉松专项基金(编号:LC2022A26)资助。

摘　　要：口腔癌是头颈颌面部位中最常见的肿瘤之一,在中国仅次于鼻咽癌位居头颈部恶性肿瘤的第2位。50%以上的口腔癌患者初诊时已处于局部晚期,或已发生远处转移。依据患者分期,基于手术、放疗、化疗、免疫治疗和靶向治疗的多学科治疗方案是目前口腔癌的治疗标准。虽然治疗模式多样,但口腔癌2/5年总生存率仍然较低,不能满足临床需求,亟需探索更加有效的综合治疗方案来改善口腔癌的整体预后。本文对近年来口腔癌多学科综合治疗新模式以及该新模式下口腔癌的放射治疗进展进行综述。Oral cancer is one of the most prevalent malignant tumors of the head and neck region.In China,the incidence of oral cancer ranks second among all cancers of the head and neck and second only to that of nasopharyngeal carcinoma.More than 50%of patients with oral cancer are either at a locally advanced stage at initial diagnosis or have already developed distant metastasis.Depending on the cancer stage in a patient,multidisciplinary treatment,including surgery,radiotherapy,chemotherapy,immunotherapy,and targeted therapy,is currently the standard treatment for oral cancer.Despite the variety of treatment modalities,the 2-/5-year overall survival rate of patients with oral cancer is rather low and cannot meet clinical needs.Therefore,there is an urgent need to develop more effective and comprehensive treatment modalities to improve the prognosis of oral cancer.In this study,we reviewed a new multidisciplinary comprehensive treatment mode for oral cancer in recent years and the progress in radiotherapy for oral cancer under this new mode.

关 键 词：口腔癌 头颈鳞癌 放射治疗 多学科综合治疗 免疫治疗 

分 类 号：R739.8[医药卫生—肿瘤] R730.55[医药卫生—临床医学]