预测甲状腺乳头状癌颈部中央区淋巴结转移生物标志物研究进展  

Advances in biomarkers for predicting central cervical lymph node metastasis in papillary thyroid carcinoma

作　　者：胡锦波 郭建平 郭文科 牛海刚[1,2] HU Jinbo;GUO Jianping;GUO Wenke;NIU Haigang(Fenyang College of Shanxi Medical University,Lyuliang,Shanxi 032200,China;Department of General Surgery,Fenyang Hospital of Shanxi Province,Lyuliang,Shanxi 032200,China)

机构地区：[1]山西医科大学汾阳学院,山西吕梁032200 [2]山西省汾阳医院普通外科,山西吕梁032200

出　　处：《安徽医药》2024年第12期2333-2339,I0001,共8页Anhui Medical and Pharmaceutical Journal

基　　金：吕梁市重点研发项目(2020SHFZ63);山西省汾阳医院科技攻关项目(202305)。

摘　　要：甲状腺癌作为常见的内分泌恶性肿瘤,发病率逐年上升。甲状腺乳头状癌作为其中最常见的病理分型,大部分病人预后较好,但颈部淋巴结转移作为其侵袭性特征,提示病人预后不良。目前国内外指南对于术前颈部淋巴结无明显转移征象病人是否需预防性行颈部中央区淋巴结清扫存在争议。液体活检具有便捷、无创等特点,多种血清标志物及基因突变靶点在甲状腺乳头状癌颈部淋巴结转移中的作用具有独特优势,并可联合影像学检查及细针穿刺活检提高诊断敏感性,但仍有不足之处。该研究就甲状腺乳头状癌颈部中央区淋巴结转移相关的部分生物标志物进行综述。As the most common endocrine malignant tumor,thyroid cancer has an increasing incidence year by year.Papillary thyroid carcinoma is its most common pathological type.Most patients have a good prognosis,but cervical lymph node metastasis is an invasive feature,suggesting a poor prognosis.At present,domestic and foreign guidelines are controversial about whether prophylactic central cervical lymph node dissection is necessary for patients with no obvious signs of preoperative cervical lymph node metastasis.Liquid biopsy has the characteristics of convenience and non-invasiveness.A variety of serum markers and gene mutation targets have unique advantages of their role in cervical lymph node metastasis of papillary thyroid carcinoma,and can be combined with imaging examination and fine needle aspiration biopsy to improve the diagnostic sensitivity,but there are still deficiencies.This article reviews some biomarkers related to central cervical lymph node metastasis in papillary thyroid carcinoma.

关 键 词：甲状腺肿瘤 肿瘤细胞 循环 癌 乳头状 颈部中央区淋巴结 肿瘤转移 生物标志物 研究进展 

分 类 号：R736.1[医药卫生—肿瘤]