FK506结合蛋白5基因多态性与抑郁症易感性及自杀行为的关系分析  

Relationship between FKBP5 gene polymorphism and susceptibility to depression and suicidal behavior

作　　者：何堂礼 邬俊福 HE Tangli;WU Junfu(Department of Quality Control,The Second People's Hospital of Shangqiu,Shangqiu,He'nan 476000,China;Department of Psychiatry,The Second People's Hospital of Shangqiu,Shangqiu,He'nan 476000,China)

机构地区：[1]商丘市第二人民医院质控科,河南商丘476000 [2]商丘市第二人民医院精神科,河南商丘476000

出　　处：《安徽医药》2024年第12期2513-2519,共7页Anhui Medical and Pharmaceutical Journal

摘　　要：目的分析FK506结合蛋白5(FKBP5)基因多态性与抑郁症易感性及自杀行为的关系。方法纳入2018年1月至2022年1月商丘市第二人民医院收治的抑郁症病人170例,设置为抑郁症组。纳入同期于该院体检的健康受试者150例,设为健康组。对两组FKBP5基因的单核苷酸多态性(SNP)位点rs1360780、rs3800373、rs4713916、rs9470080的多态性分布频率进行Hardy-Weinberg平衡检验。根据抑郁症组是否存在自杀行为将其分为自杀行为组(33例)、无自杀行为组(117例)。比较抑郁症组、健康组rs1360780、rs3800373、rs4713916、rs9470080位点的基因多态性;自杀行为组、无自杀行为组rs1360780、rs3800373、rs4713916、rs9470080位点的基因多态性;采用logistic回归模型分析FKBP5基因SNP位点与抑郁症易感性及自杀行为的关系。结果抑郁症组、健康组的FKBP5基因rs1360780、rs3800373、rs4713916、rs9470080位点的实际基因与Hardy-Weinberg遗传平衡定律预测的基因型频率比较,均差异无统计学意义(P>0.05)。与健康组(13.33%、34.33%)比较,抑郁症组rs1360780、rs3800373位点上TT基因型频率、T等位基因频率(46.67%、69.33%)均升高(P<0.05)。logistic回归分析显示,家族史[OR=2.54,95%CI:(1.54,4.21)]、严重睡眠障碍[OR=6.51,95%CI:(2.67,15.92)]、自评经济状况[OR=1.92,95%CI:(1.26,2.93)]、合并慢性病[OR=3.01,95%CI:(1.06,8.51)]及FKBP5基因rs1360780、rs3800373位点上TT基因型[OR=2.78,95%CI:(1.55,4.98);OR=3.08,95%CI:(1.49,6.39)]是抑郁症易感性的影响因素(P<0.05)。与无自杀行为组(8.55%、42.74%、21.37%、22.22%、40.17%、66.24%)比较,自杀行为组家族史、重大负性生活事件、自责、绝望百分率及rs1360780位点上TT基因型频率、T等位基因频率(27.27%、72.73%、42.42%、51.52%、69.70%、80.30%)升高(P<0.05)。logistic回归模型分析显示,家族史[OR=2.10,95%CI:(1.17,3.76)]、重大负性生活事件[OR=3.50,95%CI:(1.70,7.22)]、自责[OR=2.79,95%CI:(1.13,6.92)]、绝望[OObjective To analyze the relationship between FK506 binding protein 5(FKBP5)gene polymorphism and depression susceptibility and suicidal behavior.Methods One hundred and seventy patients with depression admitted to the Second People's Hospital of Shangqiu City from January 2018 to January 2022 were enrolled as depression group.One hundred and fifty healthy subjects who underwent physical examination in the hospital during the same period were included as the normal group.The distribution frequency of single nucleotide polymorphism(SNP)sites rs1360780,rs3800373,rs4713916 and rs9470080 of FKBP5 gene in two groups were tested by Hardy-Weinberg balance test.The depression group was divided into suicidal behavior group(33 cases)and non-suicidal behavior group(117 cases)according to whether there was suicidal behavior.The polymorphisms of rs1360780,rs3800373,rs4713916 and rs9470080 in depression group and normal group,as well as the polymorphisms of rs1360780,rs3800373,rs4713916,rs9470080 in suicidal behavior group and non-suicidal behavior group,were compared.Logistic regression model was used to analyze the relationship between the SNP locus of FKBP5 gene and depression susceptibility and suicidal behavior.Results There were no significant differences in the frequency of FKBP5 gene rs1360780,rs3800373,rs4713916 and rs9470080 compared with that predicted by Hardy-Weinberg law of genetic balance between depression group and normal group(P>0.05).Compared with normal group(13.33%and 34.33%),TT genotype frequency and T allele frequency(46.67%and 69.33%)at rs1360780 and rs3800373 sites in depression group were increased(P<0.05).Logistic regression analysis showed that family history[OR=2.54,95%CI:(1.54,4.21)],severe sleep disorder[OR=6.51,95%CI:(2.67,15.92)],self-rated economic status[OR=1.92,95%CI:(1.26,2.93)],chronic diseases[OR=3.01,95%CI:(1.06,8.51)]and TT genotype at rs1360780 and rs3800373 of FKBP5 gene[OR=2.78,95%CI:(1.55,4.98),OR=3.08,95%CI:(1.49,6.39)]were the influencing factors of depression susceptibility(P<0.0

关 键 词：抑郁症 FK506结合蛋白5 基因多态性 易感性 自杀行为 

分 类 号：R749.4[医药卫生—神经病学与精神病学]