血清IL-6 IL-17及IL-35水平与儿童急性淋巴细胞白血病病情及化疗疗效的研究  

Study on Serum IL-6 IL-17 and IL-35 Levels and Disease Condition and Chemotherapy Efficacy of Acute Lymphoblastic Leukemia in Children

作　　者：高丽娟[1] 高凤娟[1] 郭建新[1] 瞿梦婷 海力其古丽·努日丁[1] GAO Lijuan;GAO Fengjuan;GUO Jianxin(The First Affiliated Hospital of Xinjiang Medical University,Xinjiang Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院,新疆乌鲁木齐830054

出　　处：《河北医学》2024年第11期1830-1834,共5页Hebei Medicine

基　　金：新疆维吾尔自治区自然科学基金资助项目,(编号:2021D01C323)。

摘　　要：目的:分析血清白介素-6(IL-6)、白介素-17(IL-17)及白介素-35(IL-35)水平在儿童急性淋巴细胞白血病不同病情及化疗疗效中的变化。方法:将2018年10月至2023年10月本院收治的95例儿童急性淋巴细胞白血病患者依据入院检查病情严重程度分为初始期组(n=45)和进展期组(n=50),依据化疗1个周期后的疗效分为缓解组(n=70)和未缓解组(n=25)。测定所有研究对象的血清IL-6、IL-17及IL-35水平,以二元Logistic回归分析法构建以血清IL-6、IL-17及IL-35水平为变量的评估模型,以受试者特征工作曲线(ROC)分析血清IL-6、IL-17及IL-35水平对患儿病情的评估价值。结果:进展期组的血清IL-6、IL-17、IL-35水平高于初始期组(P<0.05);未缓解组的血清IL-6、IL-17、IL-35水平高于缓解组(P<0.05)。Logistic回归分析结果显示,血清IL-6、IL-17及IL-35为儿童急性淋巴细胞白血病病情进展的独立危险因素,评估模型为logit(P)=-7.052+0.206×IL-6+0.238×IL-17+0.406×IL-35。ROC曲线显示,血清IL-6、IL-17、IL-35水平联合评估儿童急性淋巴细胞白血病病情的曲线下面积(AUC)为0.918,灵敏度为80.00%,特异性为95.56%,优于各指标单独评估(P<0.05)。结论:血清IL-6、IL-17、IL-35水平在儿童急性淋巴细胞白血病不同病情及化疗疗效中存在明显差异,早期检测血清IL-6、IL-17、IL-35水平可为白血病病情评估提供一定的参考价值。Objective:To analyze the changes of serum interleukin-6(IL-6),interleukin-17(IL-17)and interleukin-35(IL-35)levels in children with acute lymphoblastic leukemia(ALL)with different disease conditions and chemotherapy efficacy.Methods:A total of 95 children with ALL admitted to the hospital from October 2018 to October 2023 were divided into initial stage group(n=45)and advanced stage group(n=50)according to the severity of admission examination.By means of efficacy after 1 cycle of chemotherapy,they were classified into remission group(n=70)and non-remission group(n=25).Serum IL-6,IL-17 and IL-35 levels were measured among the study subjects.Binary Logistic regression analysis was used to construct an evaluation model with serum IL-6,IL-17 and IL-35 levels as variables.Receiver operating characteristic curve(ROC)was applied to analyze the evaluated value of serum IL-6,IL-17 and IL-35 on disease condition of children.Results:The levels of serum IL-6,IL-17 and IL-35 of advanced stage group were higher than initial stage group(P<0.05).Serum IL-6,IL-17 and IL-35 of non-remission group were higher than remission group(P<0.05).Logistic regression analysis indicated that serum IL-6,IL-17 and IL-35 were independent risk factors for disease progression of children with ALL,and the evaluation model was logit(P)=-7.052+0.206×IL-6+0.238×IL-17+0.406×IL-35.ROC analysis suggested the AUC of serum IL-6,IL-17 and IL-35 levels combined to evaluate the severity of childhood acute lymphoblastic leukemia was 0.918,the sensitivity was 80.00%,and the specificity was 95.56%,which was better than that of each index alone(P<0.05).Conclusion:Serum levels of IL-6,IL-17 and IL-35 are significantly different among ALL children with different disease conditions and chemotherapy efficacy.Early detection of serum IL-6,IL-17 and IL-35 can provide certain reference value for the evaluation of leukemia.

关 键 词：儿童急性淋巴细胞白血病 白介素-6 白介素-17 白介素-35 化疗疗效 

分 类 号：R733.71[医药卫生—肿瘤]