三种不同方案治疗对乳腺癌患者腔镜保乳术患者残腔边缘肿瘤残留率客观缓解率及预后的影响  

Influence of Three Different Regimens on Tumor Residual Rate of Residual Cavity Edge Objective Remission Rate and Prognosis in Patients with Breast Cancer Undergoing Endoscopic Breast-Conserving Surgery

作　　者：崔仪 向辉 柯贤锋 李强[1] 雷珍珍 CUI Yi;XIANG Hui;KE Xianfeng(Shangluo Central Hospital,Shaanxi Shangluo 726000,China)

机构地区：[1]陕西省商洛市中心医院甲乳外科,陕西商洛726000

出　　处：《河北医学》2024年第11期1881-1886,共6页Hebei Medicine

基　　金：陕西省卫生健康科研基金项目,(编号:2018C006)。

摘　　要：目的:探讨乳腺癌患者应用三种不同治疗方案治疗的临床效果。方法:选取2019年2月至2022年2月我院接诊的155例乳腺癌患者,根据其治疗方案的不同分为三组,A组50例采取腔镜保乳术治疗,B组53例采取腔镜保乳术+射频消融术治疗,C组52例采取腔镜保乳术+放疗治疗,对比三组残腔边缘肿瘤残留率、临床疗效、并发症发生率、生活质量[乳腺癌患者生命质量测定量表(FACT-B)]评分以及远期预后情况。结果:A组、B组、C组残腔边缘肿瘤残留率差异无统计学意义(16.00%vs5.66%vs7.55%,P>0.05);与A组相比,B组客观缓解率更高(83.02%vs56.00%,P<0.0167),A组、B组与C组的客观缓解率比较有统计学差异(56.00%vs83.02%vs65.38%,P<0.05);A组、B组、C组术后并发症发生率差异无统计学意义(16.00%vs11.32%vs17.31%,P>0.05);术后3个月,三组FACT-B评分均较术前提高(P<0.05),且与A组、C组比较,B组升高幅度更大(P<0.05);随访2年,与A组相较,C组局部复发率更低(1.92%vs16.00%,P<0.0167),B组与C组的局部复发率比较无统计学意义(13.21%vs1.92%,P>0.05),B组与A组的局部复发率比较无统计学意义(13.21%vs16.00%,P>0.05);A组、B组、C组2年生存率比较差异无统计学意义(88.00%vs86.79%vs86.54%,P>0.05)。结论:腔镜保乳术联合射频消融术的临床疗效、患者生活质量更好,腔镜保乳术联合放疗的复发率更低,两者同单纯腔镜保乳术,具有相似的残腔边缘肿瘤残留率、并发症以及2年生存率。Objective:To explore the clinical effect of three different regimens on patients with breast cancer(BC).Methods:Totally 155 patients with BC in the hospital were selected from February 2019 to February 2022,and were divided into three groups by means of different treatment regimens.Patients in group A(n=50)were treated with endoscopic breast-conserving surgery,patients in group B(n=53)received endoscopic breast-conserving surgery+radiofrequency ablation,and patients in group C(n=52)were given endoscopic breast-conserving surgery+radiotherapy.The tumor residual rate of residual cavity edge,clinical efficacy,incidence of complications,quality of life[functional assessment of cancer therapy-breast(FACT-B)]and long-term prognosis were compared among the three groups.Results:There was no statistical significance in the residual tumor rate among group A,group B and group C(16.00%vs 5.66%vs 7.55%,P>0.05).Compared with group A,the objective response rate in group B was higher(83.02%vs 56.00%,P<0.0167),and the objective response rate was statistically different among group A,group B and group C(56.00%vs 83.02%vs 65.38%,P<0.05).There was no statistical difference in the incidence of postoperative complications among group A,group B and group C(16.00%vs 11.32%vs 17.31%,P>0.05).At 3 months after surgery,FACT-B scores in all three groups were enhanced compared with those before surgery(P<0.05),and compared with groups A and C,the increases in group B were greater(P<0.05).After 2 years of follow-up,compared with group A,the local recurrence rate in group C was lower(1.92%vs 16.00%,P<0.0167),but there was no statistical significance in the local recurrence rate between group B and group C(13.21%vs 1.92%,P>0.05),and no statistical significance was shown in the local recurrence rate between group B and group A(13.21%vs 16.00%,P>0.05).The 2-year survival rate revealed no statistical difference among groups A,B and C(88.00%vs 86.79%vs 86.54%,P>0.05).Conclusion:Endoscopic breast-conserving surgery combined with radiofrequency ablati

关 键 词：乳腺癌 腔镜保乳术 射频消融术 放疗 肿瘤残留率 

分 类 号：R737.9[医药卫生—肿瘤]