两种新合成三唑硫酮席夫碱类化合物抑菌活性研究  

Research on the Antibacterial Activity of Two Newly Synthesized Schiff Base Compounds of Triazole Thione

作　　者：郭雪 王宇[1] 王周露 唐金博 蔡明慧 王振宇 GUO Xue;WANG Yu;WANG Zhoulu;TANG Jinbo;CAI Minghui;WANG Zhenyu(School of Biomedical and Chemical Engineering,Liaoning Institute of Science and Technology,Benxi Liaoning 117004,China)

机构地区：[1]辽宁科技学院生物医药与化学工程学院,辽宁本溪117004

出　　处：《辽宁科技学院学报》2024年第5期50-54,共5页Journal of Liaoning Institute of Science and Technology

基　　金：2024年辽宁科技学院大学生创新创业训练计划项目(202411430043);2024年辽宁省教育厅科研团队项目(2024JYTKYTD-15)。

摘　　要：在众多有机化合物中,席夫碱以其独特的结构和多样的生物活性引起了研究者广泛关注。尤其在抗菌领域,三唑硫酮席夫碱类化合物要比其他类席夫碱抗菌抗癌活性更好。本研究以两种新合成三唑硫酮席夫碱类化合物——对羟基苯甲醛三唑硫酮席夫碱与5-氯水杨醛三唑硫酮席夫碱为研究对象,对大肠杆菌、金黄葡萄球菌和枯草芽孢杆菌等几种常见菌种进行抑菌实验,通过分析抑菌数据,比较两种化合物对三种菌的抑菌效果,为今后开发新型有机化合物抑菌剂提供科学依据。Among numerous organic compounds,Schiff bases have attracted widespread attention from researchers due to their unique structure and diverse biological activities.Especially in the field of antibacterial activity,triazolothione Schiff base compounds have better antibacterial and anticancer activity than other Schiff base compounds.This study focuses on two newly synthesized triazolyl sulfide Schiff base compounds-p-hydroxybenzaldehyde triazolyl sulfide Schiff base and 5-chlorosalicylaldehyde triazolyl sulfide Schiff base,and conducts antibacterial experiments on several common bacterial strains,such as Escherichia coli,Staphylococcus aureus,and Bacillus subtilis.By analyzing antibacterial data,the antibacterial effects of the two compounds on the three bacteria are compared,and the results can offer scientific basis for the development of new organic compound antibacterial agents in the future.

关 键 词：三唑类化合物 席夫碱 滤纸片法 抑菌圈直径 抑菌活性 

分 类 号：O626[理学—有机化学]