Gold nanoclusters encapsulated microneedle patches with antibacterial and self-monitoring capacities for wound management  

作　　者：Kexin Yi Yunru Yu Lu Fan Li Wang Yu Wang Yuanjin Zhao 

机构地区：[1]Department of Rheumatology and Immunology,Institute of Translational Medicine,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing,China [2]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,Zhejiang,China [3]Shenzhen Research Institute,Southeast University,Shenzhen,Chin

出　　处：《Aggregate》2024年第3期315-327,共13页聚集体（英文）

基　　金：National Key Research and Development Program of China,Grant/Award Number:2020YFA0908200;National Natural Science Foundation of China,Grant/Award Numbers:52073060,61927805;Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2021B1515120054;Shenzhen Fundamental Research Program,Grant/Award Number:JCYJ20210324133214038。

摘　　要：The management of infected wounds is always of great significance and urgency in clinical and biomedicalfields.Recent efforts in this area are focusing on the development of functional wound patches with effective antibacterial,drug delivery,and sensor properties.Here,we present novel hyaluronic acid(HA)microneedle patches with these features by encapsulating aminobenzeneboronic acid-modified gold nanoclusters(A-GNCs)for infected wound management.The A-GNCs loaded microneedle patches were derived from negative-mold replication and showed high mechanical strength to penetrate the skin.The release of the A-GNCs was realized by the degradation of HA,and the self-monitor of the released actives was based on the dynamic bright orangefluorescence emitted from A-GNCs under ultravio-let radiation.As the A-GNCs could destroy bacteria membranes,the microneedle patches were with excellent in vitro antibiosis ability.Based on these features,we have demonstrated the bacteria inhibition,residual drug self-monitoring,and wound healing promotion abilities of the microneedle patches in Escherichia coli-or Staphylococcus aureus-infected wound management.These results indicated the great potential of such A-GNCs loaded microneedle patches for clinical applications.

关 键 词：ANTIBACTERIAL gold nanocluster MICRONEEDLE patch sensor wound healing 

分 类 号：O64[理学—物理化学]