Supramolecular phthalocyanine assemblies-enhanced synergistic photodynamic and photothermal therapy guided by photoacoustic imaging  

作　　者：Yuan-Yuan Zhao Xiaojun Zhang Zixuan Chen Yihui Xu Heejeong Kim Hyunsun Jeong You Rim Lee Jiah Lee Xingshu Li Juyoung Yoon 

机构地区：[1]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy,College of Chemistry,Fuzhou University,Fuzhou,China [2]Department of Chemistry and Nanoscience,Ewha Womans University,Seoul,South Korea

出　　处：《Aggregate》2024年第3期328-337,共10页聚集体（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:22078066,T2322004;National Research Foundation of Korea,Grant/Award Number:2022R1A2C3005420;Ewha Womans University。

摘　　要：Phototherapeutic nanoplatforms that combine photodynamic therapy(PDT)and photothermal therapy(PTT)with the guidance of photoacoustic(PA)imaging are an effective strategy for the treatment of tumors,but establishing a universal method for this strategy has been challenging.In this study,we present a supramolecular assem-bly strategy based on Förster resonance energy transfer to construct a supramolecular nanostructured phototherapeutic agent(PcDA)via the anion and cation supramolec-ular interaction between two water-soluble phthalocyanine ramifications,PcD and PcA.This approach promotes the absorption of energy,thus enhancing the genera-tion of reactive oxygen species(ROS)and heat by PcDA,improving its therapeutic efficacy,and overcoming the low photon utilization efficiency of conventional PSs.Notably,after the intravenous injection of PcDA,neoplastic sites could be clearly visualized using PA imaging,with a PA signal-to-liver ratio as high as 11.9.Due to these unique features,PcDA exhibits excellent antitumor efficacy in a preclinical model at a low dose of light irradiation.This study thus offers a general approach for the development of efficient phototherapeutic agents based on the simultaneous effect of PDT and PTT against tumors with the assistance of PA imaging.

关 键 词：Förster resonance energy transfer photoacoustic imaging photodynamic therapy photothermal therapy supramolecular assembly 

分 类 号：R730.5[医药卫生—肿瘤]