Elaborately engineered Au(I)-based AIEgens: Robust and broad-spectrum elimination abilities toward drug-resistant bacteria  

作　　者：Shuangling Deng Zhen Peng Fang Zhou Guanqing Zhong Zhen Cai Xiaodong Tang Changhuo Xu Lei Zheng Ben Zhong Tang Jing Zhang 

机构地区：[1]Department of Laboratory Medicine,Nanfang Hospital,Southern Medical University,Guangzhou,China [2]National Key Laboratory of Green Pesticide,College of Chemistry,Central China Normal University,Wuhan,China [3]Guangdong Provincial Key Laboratory of New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,China [4]MOE Frontiers Science Center for Precision Oncology,Faculty of Health Sciences,University of Macao,Taipa,Macao,China [5]School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,The Chinese University of Hong Kong,Shenzhen,Guangdong,China

出　　处：《Aggregate》2024年第5期274-286,共13页聚集体（英文）

基　　金：Basic and Applied Basic Research Foundation of Guangdong Province,Grant/Award Numbers:2021A1515110373,2023A1515011924;Science and Technology Planning Project of Guangzhou-Basic and Applied Basic Research Project,Grant/Award Number:202201011505;Major Scientific and Technological Special Project in the Precision Medical Field of Guangdong Province,Grant/Award Number:2019B020232003;National Key Research and Development Program of China,Grant/Award Numbers:2021YFA1300604,2021YFE0202400;National Natural Science Foundation of China,Grant/Award Numbers:22205096,31971293;Outstanding Youths Development Scheme of Nanfang Hospital,Southern Medical University,Grant/Award Number:2021J002;National Science Fund for Distinguished Young Scholars,Grant/Award Number:82025024。

摘　　要：Antimicrobial resistance(AMR)remains an urgent and formidable challenge to global public health.Developing new medicines or alternative therapies to address AMR is imperative.Herein,we rationally designed and synthesized a series of Au(I)-based aggregation-induced emission luminogens(AIEgens)to combat drug-resistant bacterial infections.Through systematic screening,we identified an optimal AIEgen,called complex 5,which can rapidly discriminate between gram-positive(G^(+))and gram-negative bacteria(G^(-))bacteria,and exert robust and broad-spectrum antimicrobial potency against diverse drug-resistant bacterial strains,including those intractable to treat in clinic.Furthermore,extensive testing against a variety of clinical drug-resistant isolates,coupled with the successful treatment of methicillin-resistant Staphylococcus aureus-infected skin wounds unequivocally validates the high efficiency and broad-spectrum activity of complex 5.Therefore,complex 5 emerges as a promising candidate for combating drug-resistant bacterial infections in clinic,and this work provides inspiration for developing new solutions to address the escalating global challenge of AMR.

关 键 词：aggregation-induced emission ANTIBACTERIA gold(I)complex PHOTOTHERAPY 

分 类 号：O17[理学—数学]