Atomic-iodine-substituted polydiacetylene nanospheres with boosted intersystem crossing and nonradiative transition through complete radiative transition blockade for ultraeffective phototherapy  

作　　者：Dan Zhao Lingling Zhang Mingming Yin Zhenyan He Fang Fang Minle Zhan Sidan Tian Fanling Meng Liang Luo 

机构地区：[1]National Engineering Research Center for Nanomedicine,College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan,China [2]Key Laboratory of Molecular Biophysics of the Ministry of Education,College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan,China [3]Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica,School of Chemistry and Chemical Engineering,Huazhong University of Science and Technology,Wuhan,China

出　　处：《Aggregate》2024年第5期287-296,共10页聚集体（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:22077038,52325304,21877042;Huazhong University Supportive Fund for Fundamental Research。

摘　　要：The energy dissipation pathways of a photosensitizer for phototherapies,including photodynamic therapy(PDT)and photothermal therapy(PTT),compete directly with that of itsfluorescence(FL)emission.Enriching heavy atoms on theπ-conjugated systems and aggregation-caused quenching are two effective methods to turn off the FL emission of photosensitizers,which is expected to boost the inter-system crossing(for PDT)and nonradiative transition(for PTT)of photosensitizers for maximized phototherapeutic efficacy.Following this approach,an all-iodine-substituted polydiacetylene aggregate poly(diiododiacetylene)(PIDA)has been developed,which shows a superior near infrared absorption(ε_(808nm)=26.1 g^(-1) cm^(-1) L)with completely blocked FL,as well as high efficiency of reactive oxygen species generation(nearly 45 folds of indocyanine green)and photothermal conversion(33.4%).To make the insolublefibrillar PIDA aggregates favorable for systemic administration,they are converted into nanospheres through a pre-polymerization morphology transformation strategy.The in vivo study on a 4T1 tumor-bearing mouse model demonstrates that PIDA nanospheres can almost eliminate the tumor entirely in 16 days and prolong the survival time of mice to over 60 days,validating their effective phototherapeutic response through the strategy of inhibiting FL for boosted intersystem crossing and nonradiative transition.

关 键 词：blockedfluorescence emission heavy atom effect morphology transformation PHOTOTHERAPY polydi-acetylene aggregate 

分 类 号：O657.3[理学—分析化学]