Bio-inspired temporospatial catalytic cascades systems based on ultrasound-triggered multicomponent piezoelectric microparticles  

作　　者：Danqing Huang Jinglin Wang Xiao Fu Yuanjin Zhao Lingyun Sun 

机构地区：[1]Department of Rheumatology and Immunology,Institute of Translational Medicine,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,China [2]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing,China

出　　处：《Aggregate》2024年第4期165-172,共8页聚集体（英文）

基　　金：National Key Research and Development Program of China,Grant/Award Number:2020YFA0908200;National Natural Science Foundation of China,Grant/Award Numbers:52073060,81720108022;Nanjing Medical Science and Technique Development Foundation,Grant/Award Number:ZKX21019;Clinical Trials from Nanjing Drum Tower Hospital,Grant/Award Number:2022-LCYJ-ZD-01。

摘　　要：Reactive oxygen species(ROS)have certain effect in cancer treatment,thus many studies have been focused on developing functional systems to generate ROS in tumor.Here,inspired by the multi-enzyme biocatalysis in organisms,novel ultrasound-triggered temporospatial catalytic cascades systems are presented based on barium titanate(BTO)and platinum(Pt)co-loaded multi-component micropar-ticles(Pt/BTO@MCMPs)to successively achieve oxygen and ROS production for tumor sonodynamic therapy.By using a customized capillary microfluidic device,the Pt/BTO@MCMPs are fabricated with Pt nanoparticles located in their core part and BTO nanocubes located in their peripheral part,alternating with blank porous hydrogel components for increasing interaction areas between the encap-sulated nanomaterials and the ambient substrates.In the microparticles,the Pt can catalyze hydrogen peroxide from the tumor microenvironment to generate O_(2) and H_(2)O serving as substrates for piezoelectric catalytic reactions,contributing to additional generation of ROS under US activation.Based on the system,it is demon-strated that the Pt/BTO@MCMPs are featured with excellent biocompatibility under normal biological conditions and show desired tumor eradication properties under ultrasound irradiation in mice carrying pancreatic tumors.These results indicate that the proposed ultrasound-triggered temporospatial catalytic cascades systems are promising for clinic anti-tumor applications.

关 键 词：ANTI-TUMOR barium titanate microfluidics platinum temporospatial catalysis ULTRASOUND 

分 类 号：O64[理学—物理化学]