结直肠癌患者CT影像表现及其与血清miR-497、CA24-2、HBsAg表达水平的相关性  

Correlation between CT findings and expression levels of serum miR-497,CA24-2 and HBsAg in patients with colorectal cancer

作　　者：寻梦雅 吴霞 桂亮[2] 赵玉年[1] 贾张军 尹娜[4] Xun Mengya;Wu Xia;Gui Liang;Zhao Yunian;Jia Zhangjun;Yin Na(Department of Radiology,Jiangsu Cancer Hospital,Nanjing 21009,China;General Surgery,Jiangsu Cancer Hospital,Nanjing 210009,China;Department of Clinical Laboratory,Jiangsu Cancer Hospital,Nanjing 210009,China;Imaging Center,Jiangsu Cancer Hospital,Nanjing 210009,China)

机构地区：[1]江苏省肿瘤医院放射科,南京210009 [2]江苏省肿瘤医院普外科,南京210009 [3]江苏省肿瘤医院检验科,南京210009 [4]江苏省肿瘤医院影像中心,南京210009

出　　处：《中国医师杂志》2024年第11期1647-1651,共5页Journal of Chinese Physician

基　　金：江苏省卫生健康委科研课题(BJ19032)。

摘　　要：目的探讨结直肠癌(CRC)患者CT影像表现及其与血清微小RNA-497(miR-497)、糖类多肽抗原24-2(CA24-2)、乙型肝炎表面抗原(HBsAg)表达水平的相关性。方法前瞻性选择2021年1月至2022年12月江苏省肿瘤医院收治的64例CRC患者,以手术病理结果为金标准。所有患者术前均行CT检查以及血清miR-497、CA24-2、HBsAg水平检测。分析患者的CT影像表现。采用Pearson相关性分析评估CRC患者CT影像表现与血清miR-497、CA24-2、HBsAg表达水平的相关性。结果CRC患者的CT影像特征主要表现:肠壁半环形占37.50%(24/64)、环形占32.81%(21/64)、局限性增厚占29.69%(19/64),肠腔存在不规则狭窄,大部分肠周脂肪模糊不清占59.38%(38/64),增强扫描大多数为不均匀强化占67.19%(43/64),发生淋巴结转移的占51.56%(33/64),发生肝转移的占43.75%(28/64)。CRC患者淋巴结转移与血清miR497、CA24-2水平表达有关(均P<0.05)而与血清HBsAg水平无关(P>0.05)。CRC患者肝转移与血清HBsAg水平表达有关(P<0.05),而与血清miR-497、CA24-2水平无关(均P>0.05)。CRC患者其他CT影像表现与血清miR-497、CA24-2、HBsAg水平表达均无关(均P>0.05)。Pearson相关分析显示,CRC患者发生淋巴结转移与血清miR-497表达水平呈负相关(r=-0.491,P<0.05),而与血清CA24-2表达水平呈正相关(r=0.506,P<0.05),与血清HBsAg表达水平无相关性(P>0.05);CRC患者发生肝转移与血清HBsAg表达水平呈负相关(r=-0.529,P<0.05),与血清miR497、CA24-2表达水平无相关性(均P>0.05)。结论CT影像表现可在一定程度上评估CRC患者肿瘤细胞的生物学行为,与血清miR497、CA24-2、HBsAg表达水平具有一定相关性,可反映肿瘤的淋巴结、肝转移情况,可为临床综合治疗以及预测患者预后提供依据。Objective To investigate the correlation between computed tomography(CT)findings and serum micrornA-497(miR-497),carbohydrate polypeptide antigen 24-2(CA24-2)and hepatitis B surface antigen(HBsAg)expression in patients with colorectal cancer(CRC).Methods A total of 64 CRC patients admited to the Jiangsu Cancer Hospital from January 2021 to December 2022 were prospectively selected,and the surgical pathological results were used as the gold standard.Preoperative CT examination and serum miR-497,CA24-2 and HBsAg levels were performed in all patients.The CT images of the patients were analyzed.Pearson correlation analysis was used to evaluate the correlation between CT findings and serum miR-497,CA24-2 and HBsAg expression levels in CRC patients.Results The CT imaging features of CRC patients were as follows:The intestinal wall was semi-annular in 37.50%(24/64),annular in 32.81%(21/64),localized thickening in 29.69%(19/64),the intestinal lumen was irregular and narrow,and most of the perintestinal fat was blurred in 59.38%(38/64).67.19%(43/64)showed uneven enhancement,51.56%(33/64)had lymph node metastasis and 43.75%(28/64)had liver metastasis.Lymph node metastasis in CRC patients was correlated with serum miR-497 and CA24-2 levels(all P<0.05),but not with serum HBsAg levels(P>0.05).Liver metastasis in CRC patients was associated with serum HBsAg expression(P<0.05),but not with serum miR-497 and CA24-2 levels(all P>0.05).Other CT findings of CRC patients were not correlated with serum miR-497,CA24-2 and HBsAg levels(all P>0.05).Pearson correlation analysis showed that lymph node metastasis in CRC patients was negatively correlated with the expression level of serum miR-497(r=-0.491,P<0.05),while positively correlated with the expression level of serum CA24-2(r=0.506,P<0.05).There was no correlation with serum HBsAg expression level(P>0.05).The occurrence of liver metastasis in CRC patients was negatively correlated with the expression level of serum HBsAg(r=-0.529,P<0.05),but was not correlated with the expression l

关 键 词：结直肠肿瘤 体层摄影术 螺旋计算机 miR-497 CA-24-2抗原 乙型肝炎表面抗原 

分 类 号：R735.34[医药卫生—肿瘤]