泛凋亡机制与临床研究进展  

The mechanism of panapoptosis and clinical research progress

作　　者：王鑫 朱峰 付忠华[1] Wang Xin;Zhu Feng;Fu Zhonghua(Burn Plastic Surgery and Wound Repair Medical Center of the First Affiliated Hospital of Nanchang University Nanchang 330000,Chain;Department of Critical Care Medicine,Shanghai East Hospital,Tongji University School of Medicine,Shanghai 200120,China)

机构地区：[1]南昌大学第一附属医院烧伤整形与创面修复医学中心,南昌330000 [2]同济大学医学院附属东方医院重症医学科,上海200120

出　　处：《中国医师杂志》2024年第11期1739-1743,共5页Journal of Chinese Physician

基　　金：国家自然科学基金(82160380);江西省自然科学基金(20232BAB206082)。

摘　　要：泛凋亡是目前研究的新热点, 本质上是细胞的炎症性程序性死亡, 具有焦亡、凋亡、坏死性凋亡的共同特征。泛凋亡与多种疾病密切相关, 如感染性疾病、肿瘤、神经退行性疾病等。作为免疫系统识别和激活的途径, 虽然具体调控机制尚未明确, 泛凋亡在控制炎症扩散及疾病进展中发挥着重要作用。本综述拟探讨泛凋亡在细胞炎症及疾病发生、发展中的作用, 寻找潜在干预靶点, 为临床疾病治疗提供新策略。Panapoptosis is a new focus of current research,which is essentially the inflammatory programmed cell death,with the common characteristics of pyrodeath,apoptosis and necrotic apoptosis.Panapoptosis is closely related to many diseases,such as infectious diseases,tumors,neurodegenerative diseases and so on.As a pathway of recognition and activation by the immune system,panapoptosis plays an important role in controlling the spread of inflammation and disease progression,although the specific regulatory mechanism is not yet clear.This review aims to explore the role of panapoptosis in the pathogenesis and development of cellular inflammation and diseases,and seek potential intervention targets to provide new strategies for clinical disease treatment.

关 键 词：泛凋亡 焦亡 凋亡 坏死性凋亡 

分 类 号：R363[医药卫生—病理学]