急性大血管闭塞性缺血性卒中血管内治疗无效再通的研究进展  

Research progress of recanalization after ineffective endovascular therapy in acute large vascular occlusiveischemicstroke

作　　者：杨周婧妮 赵志鸿[1] 邹建军[2] Yang Zhoujingni;Zhao Zhihong;Zou Jianjun(Department of Neurology,Hunan Provincial People's Hospital(the First Affiliated Hospital of Hunan Normal University),Changsha 410005,China;Department of Pharmacy,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China)

机构地区：[1]湖南省人民医院(湖南师范大学附属第一医院)神经内科,长沙410005 [2]南京医科大学附属南京医院药学部,南京210006

出　　处：《中国医师杂志》2024年第11期1743-1747,共5页Journal of Chinese Physician

基　　金：湖南省自然科学基金(2021JJ70021);湖南省卫生健康高层次人才重大科研专项(20230393)。

摘　　要：急性缺血性卒中是威胁中老年人群生命健康的一大疾病,而血管内治疗是急性缺血性卒中最快速、有效的治疗手段。但临床发现,常有位于时间窗内或超时间窗血管内治疗的患者在血管再通后无法达到90d功能独立,即为无效再通。无效再通严重影响血管内治疗的疗效,成为神经科医师临床研究的重点。本文对近年有关急性大血管闭塞性缺血性卒中无效再通的发生机制、影响因素,以及减少其发生的可能方法进行了综合梳理,为临床医生制定更加合理完善的方案提供参考。Acute ischemic stroke is a major disease threatening the life and health of middle-aged and elderly people,and intravascular therapy is the most rapid and effective treatment for acute ischemic stroke.However,clinical findings showed that patients who were often treated intravascular within the time window or beyond the time window could not achieve functional independence for 90 days after vascular recanalization,that is,ineffective recanalization.Ineffective recanalization seriously affects the efficacy of intravascular therapy and has become the focus of clinical research by neurologists.In this paper,the mechanism and influencing factors of ineffective recanalization in acute large vascular occlusive ischemic stroke in recent years,as well as possible ways to reduce its occurrence,are comprehensively reviewed,providing references for clinicians to develop more reasonable and perfect programs.

关 键 词：急性缺血性卒中 血管内治疗 无效再通 

分 类 号：R743.3[医药卫生—神经病学与精神病学]