枯草芽孢杆菌胶囊对溃疡性结肠炎患者炎症因子、氧化应激和肠黏膜功能的影响  

Clinical Efficacy of Intestinal Microecological Changes Induced by B.Subtilis Against Ulcerative Colitis

作　　者：王健[1] 赵会君 史以超 刘辉[1] 田鑫磊 李成[1] WANG Jian;ZHAO Huijun;SHI Yichao;LIU Hui;TIAN XinLei;LI Cheng(The Jingxi Medical District,the PLA General Hospital,Beijing 100089,China;Department of Gastroenterology,Beijing Children's Hospital,Capital Medical University,Beijing 100045,China;Department of Gastroenterology,Beijing Aerospace Center Hospital,Beijing 100049,China)

机构地区：[1]解放军总医院京西医疗区,北京100089 [2]首都医科大学附属北京儿童医院消化内科,北京100045 [3]北京航天中心医院消化内科,北京100049

出　　处：《转化医学杂志》2024年第4期564-567,共4页Translational Medicine Journal

基　　金：军队保健专项(18BJZ39)。

摘　　要：目的探讨枯草芽孢杆菌胶囊对溃疡性结肠炎(UC)患者炎症因子、氧化应激和肠黏膜功能的影响。方法选择2022年3月至2023年3月解放军总医院京西医疗区收治的UC患者118例作为研究对象,根据治疗方案分为对照组和研究组各59例。对照组采用康复新液保留灌肠治疗,研究组在对照组基础上口服枯草芽孢杆菌胶囊治疗。比较2组患者治疗前后炎症因子、氧化应激和肠黏膜功能的改善情况。结果治疗后,研究组患者炎症因子C反应蛋白(CRP)、白细胞介素-1β(IL-1β)和白细胞介素-8(IL-8)水平均低于对照组,而研究组氧化应激指标超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的水平高于对照组,丙二醛(MDA)水平低于对照组,差异均有统计学意义(P<0.05)。研究组患者肠黏膜功能指标D-乳酸(D-LAC)、乳酸(LAC)、脂多糖(LPS)和二胺氧化酶(DAO)水平均低于对照组,差异有统计学意义(P<0.05)。结论枯草芽孢杆菌胶囊治疗UC可调节炎症因子、氧化应激指标水平,改善肠黏膜功能。Objective To investigate the effect of probiotic Bacillus subtilis capsule on intestinal mucosal function and the changes of intestinal flora in patients with ulcerative colitis(UC).Methods A total of 118 patients with UC from March 2022 to March 2023 were enrolled.The patients were divided into a control group(59 cases)and a study group(59 cases).The control group was treated with conventional therapy,while the study group was treated with Bacillus subtilis capsule on the basis of the control group.The improvement in intestinal mucosal f unction and the change in intestinal flora caused by Bacillus subtilis were compared between the two groups.Results After treatment,the levels of inflammatory factors,including CRP,IL-1β,and IL-8,in the study group were lower than those in the control group,while the levels of SOD and GSH-Px in the study group were higher than those in the control group.The MDA levels in the study group were lower than those in the control group.These differences were statistically significant(P<0.05).Additionally,the levels of D-lactate,LAC,LPS,and DAO in the study group were also lower than those in the control group(P<0.05).Conclusion Bacillus subtilis capsule can effectively regulate inflammatory factors and oxidative stress indicators and improve intestinal mucosal function in the treatment of UC.

关 键 词：结肠炎 溃疡性 枯草芽孢杆菌 肠黏膜功能 白细胞介素8 白细胞介素1Β 

分 类 号：R574.621[医药卫生—消化系统]