ProTaper机用镍钛锉在磨牙根管治疗中的应用及对患者龈沟液基质金属蛋白酶-8、基质金属蛋白酶-2、白细胞介素-8水平的影响  

The Application of Nickel-Titanium File with ProTaper in Root Canal Treatment of Molar and Its Influence on MMP-8,MMP-2,and IL-8 Levels in Gingival Fluid

作　　者：汪世超[1] 林苇[2] 葛宇[3] WANG Shichao;LIN Wei;GE Yu(Zhou Gudui Clinic of Hefei Stomatological Hospital(Hefei Clinical College of Stomatology,Anhui Medical University),Hefei,Anhui 230032,China;Department of Stomatology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China;Department of Orthodontics,Hefei Stomatological Hospital(Hefei Clinical College of Stomatology,Anhui Medical University),Hefei,Anhui 230032,China.)

机构地区：[1]安徽省合肥市口腔医院(安徽医科大学合肥口腔临床学院)周谷堆门诊,合肥230032 [2]安徽医科大学第一附属医院口腔科,合肥230032 [3]安徽省合肥市口腔医院(安徽医科大学合肥口腔临床学院)正畸一科,合肥230032

出　　处：《转化医学杂志》2024年第4期576-579,共4页Translational Medicine Journal

基　　金：2020年度安徽医科大学科研基金(2020xkj153)。

摘　　要：目的探究ProTaper机用镍钛锉用于磨牙根管治疗(RCT)的充填效果,并分析其对患者龈沟液基质金属蛋白酶(MMP)-8、MMP-2及白细胞介素(IL)-8水平的影响。方法选取安徽省合肥市口腔医院口腔内科2019年1月至2023年8月收治的磨牙RCT患者80例作为研究对象,根据不同预备方式分为研究组(ProTaper机用镍钛锉预备,n=43)与对照组(不锈钢K锉预备,n=37)。对比2组根管预备/充填情况及龈沟液MMP-8、MMP-2、IL-8水平变化。结果研究组根管预备时间显著短于对照组(P<0.05)。研究组适充率(95.35%vs 81.08%)显著大于对照组(P<0.05)。研究组根管预备形态好率为97.67%,与对照组(86.49%)比较差异无统计学意义(P>0.05)。研究组术后72 h龈沟液MMP-8、MMP-2、IL-8水平较术前均显著下降,且均低于同时间点对照组(P<0.05)。结论ProTaper机用镍钛锉用于磨牙RCT的充填效果较好,相比不锈钢K锉预备能显著缩短根管预备时间,降低龈沟液MMP-8、MMP-2、IL-8水平。Objective To investigate the filling effect of nickel-titanium file with ProTaper in root canal treatment(RCT)of molars as well as its impact on matrix metalloproteinase(MMP-8,MMP-2)and interleukin(IL-8)levels in gingival fluid.Methods A total of 80 patients who received molar RCT in Hefei Stomatology Hospital from January 2019 to August 2023 were divided into the study group(ProTaper with nickel-titanium file,n=43)and the control group(stainless steel K file,n=37).Root canal preparation/filling outcomes and changes in MMP-8,MMP-2,and IL-8 levels in gingival fluid were compared between the two groups.Results The study group had significantly shorter root canal preparation time compared to the control group(P<0.05).The filling rate in the study group was significantly higher than in the control group(95.35%vs 81.08%,P<0.05).There was no significant difference in the rate of good root canal preparation between the two groups(97.67%vs 86.49%,P>0.05).The levels of MMP-8,MMP-2,and IL-8 in gingival fluid decreased significantly in the study group 72 hours after surgery and were lower than those in the control group(P<0.05).Conclusions Nickel-titanium file with ProTaper demonstrated better filling effects than stainless steel K file,significantly shortening root canal preparation time and reducing MMP-8,MMP-2,and IL-8 levels in gingival fluid.

关 键 词：根管治疗 PROTAPER机用镍钛锉 基质金属蛋白酶 白细胞介素-8 

分 类 号：R781.05[医药卫生—口腔医学]