Injectable and in situ foaming shape-adaptive porous Bio-based polyurethane scaffold used for cartilage regeneration  

作　　者：Abudureheman Bahatibieke Shuai Wei Han Feng Jianming Zhao Mengjiao Ma Junfei Li Yajie Xie Kun Qiao Yanseng Wang Jiang Peng Haoye Meng Yudong Zheng 

机构地区：[1]School of Materials Science and Engineering,University of Science and Technology Beijing,Beijing,100083,China [2]Institute of Orthopaedics,Chinese PLA General Hospital,Beijing,100853,China [3]Department of Orthopedics,The Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu,215004,China [4]Hebei North University,Zhangjiakou,075000,Hebei Province,China

出　　处：《Bioactive Materials》2024年第9期1-13,共13页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(Nos.52273119,51973018 and 81571410);the Beijing Science and Technology Project(Z191100002019017).

摘　　要：Irregular articular cartilage injury is a common type of joint trauma,often resulting from intense impacts and other factors that lead to irregularly shaped wounds,the limited regenerative capacity of cartilage and the mismatched shape of the scaffods have contributed to unsatisfactory therapeutic outcomes.While injectable materials are a traditional solution to adapt to irregular cartilage defects,they have limitations,and injectable materials often lack the porous microstructures favorable for the rapid proliferation of cartilage cells.In this study,an injectable porous polyurethane scaffold named PU-BDO-Gelatin-Foam(PUBGF)was prepared.After injection into cartilage defects,PUBGF forms in situ at the site of the defect and exhibits a dynamic microstructure during the initial two weeks.This dynamic microstructure endows the scaffold with the ability to retain substances within its interior,thereby enhancing its capacity to promote chondrogenesis.Furthermore,the chondral repair efficacy of PUBGF was validated by directly injecting it into rat articular cartilage injury sites.The injectable PUBGF scaffold demonstrates a superior potential for promoting the repair of cartilage defects when compared to traditional porous polyurethane scaffolds.The substance retention ability of this injectable porous scaffold makes it a promising option for clinical applications.

关 键 词：INJECTABLE In situ forming POLYURETHANE Cartilage repair Tissue engineering 

分 类 号：R318[医药卫生—生物医学工程]