INJECTABLE

作品数：216被引量：502H指数：10
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相关领域：医药卫生更多>>
相关作者：林向进更多>>
相关机构：浙江大学医学院附属第一医院中山大学第三军医大学上海中医药大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金广东省自然科学基金国家重点基础研究发展计划更多>>
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Injectable cartilage microtissues based on 3D cultureusing porous gelatin microcarriers for cartilagedefect treatment
《Regenerative Biomaterials》2025年第1期72-83,共12页Jing Zhu Qiuchen Luo Tiefeng Cao Guang Yang Lin Xiao 
supported by the National Natural Science Foundation of China(52173151,82002734,51803067);the Natural Science Foundation of Guangdong Province of China(2021A1515011084,2019A1515110312);the Fundamental Research Funds for the Central Universities(22qntd1302);the Shenzhen Outbound Postdoctoral Scientific Research Fund(SZBH202108).
Cartilage tissues possess an extremely limited capacity for self-repair,and current clinical surgical approaches for treating articular cartilage defects can only provide short-term relief. Despite significantadvances...
关键词：cartilage repair microtissue engineering MICROCARRIERS GELATIN BMSCS 
Injectable agents for the induction of Peyronie’s disease in model rats:a comparative study
《Asian Journal of Andrology》2025年第1期96-100,共5页Guang-Jun Du Si-Yan Xing Ning Wu Tong Wang Yue-Hui Jiang Tao Song Bai-Bing Yang Yu-Tian Dai 
supported by the National Natural Science Foundation of China(grant No.81971380 and No.82301822).
Peyronie’s disease(PD)is a disorder characterized by fibrous plaque formation in the penile tissue that leads to curvature and complications in advanced stages.In this study,we aimed to compare four injectable induct...
关键词：FIBRIN Peyronie’s disease POLIDOCANOL rat model sodium tetradecyl sulfate TGF-β1 
Injectable drug-loaded thermosensitive hydrogel delivery system for protecting retina ganglion cells in traumatic optic neuropathy
《Regenerative Biomaterials》2025年第1期178-194,共17页Lei Wang Yan Jiang Yili Yao Yudan Deng Zhiqiang Liu Jiangtao Ding Wenwen Wang Hao Chen Kaihui Nan Lingli Li 
supported by Natural Science Foundation of Zhejiang Province(LY24C100002);Wenzhou Science and Technology Foundation(Y20210266);Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province(WIUCASK20004);Zhejiang Engineering Research Center for Tissue Repair Materials(WIUCASZZXF21002);Joint Medical Research Center of Xiangshan Hospital Affiliated to Wenzhou Medical University and Wenzhou Institute of Chinese Academy of Sciences(WIUCAS)(XSZX09);startup grant from WIUCAS(WIUCASQD2023022,WIUCASQD2022035).
Currently,generalized therapy for traumatic optic neuropathy(TON)is lacking.Various strategies have been developed to protect and regenerate retinal ganglion cells(RGCs)after TON.Intravitreal injection of supplements ...
关键词：TON retinal ganglion cells thermosensitive hydrogel CNTF TA 
Injectable chitosan microspheres resisting inflammatory and oxidativestress for ameliorating intervertebral disc degeneration
《Science China Materials》2025年第2期610-625,共16页Lin Huang Wantao Wang Lei Liu Wenzheng Ma Jinghao Fan Dan Zhou Lei Zhao Zhaomin Zheng Hongmei Liu Decheng Wu 
supported by the Ministry of Science and Technology of China (2020YFA0908900);National Natural Science Foundation of China (21935011);Shenzhen Science and Technology Innovation Commission (KQTD20200820113012029, JCYJ20220530114409020, and 20231115134555001);Guangdong Provincial Key Laboratory of Advanced Biomaterials (2022B1212010003)。
The treatment of intervertebral disc (IVD) degeneration remains a significant challenge due to the uniqueischemic structure of the IVD, which comprises the scavengingof inflammatory cytokines, alleviation of cellular ...
关键词：chitosan microsphere nanozymes inflammatory relieving oxidative stress regulation intervertebral disc degeneration 
Corrigendum to“Ultrasound augmenting injectable chemotaxis hydrogel for articular cartilage repair in osteoarthritis”[Chinese Chemical Letters 32(2021)1759-1764]
《Chinese Chemical Letters》2025年第2期563-565,共3页
Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis
《Nano-Micro Letters》2024年第12期59-80,共22页Qing Chen Miao Yan Annan Hu Bing Liang Hongwei Lu Lei Zhou Yiqun Ma Chao Jia Dihan Su Biao Kong Wei Hong Libo Jiang Jian Dong 
supported by the National Natural Science Foundation of China(No.52103171,82172738,82272457,22305044);China Postdoctoral Science Foundation(2023M730638);“Technology Innovation Action Plan”of Science and Technology Commission of Shanghai Municipality(21S11902700);Natural Science Foundation of Shanghai(21ZR1412300),Shanghai Science and Technology program(23Y31900202,23010502600);Shanghai“Rising Stars of Medical Talent”Youth Development Program(Youth Medical Talents-Specialist Program,[2020]087);Medical Engineering fund of Fudan University(yg2023-27).
Surgery remains the standard treatment for spinal metastasis.However,uncontrolled intraoperative bleeding poses a significant challenge for adequate surgical resection and compromises surgical outcomes.In this study,w...
关键词：Silk fibroin Nanofibril hydrogels Nanorobots THROMBIN Spinal metastasis 
Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation
《Engineered Regeneration》2024年第4期482-494,共13页Guang Yang Zili Guo Xiangfeng Zhang Jiayu Chen Jie Weng Jiapeng Bao Xiaohua Yu 
supported by the National Natural Science Foundation of China(Grant No.82372381,52071277);the National Natural Science Foundation of Zhejiang Province(Grant No.LY23H060013).
Repair of large bone defects remains to be clinically challenging,yet current bone repair strategies focus on optimizing the osteogenic capacity of bone grafts,while the role of osteoclasts in bone regeneration has be...
关键词：Bone regeneration DENOSUMAB OSTEOCLASTOGENESIS OSTEOGENESIS 
Injectable hyaluronate/collagen hydrogel with enhanced safety and efficacy for facial rejuvenation
《Collagen and Leather》2024年第4期82-97,共16页Lu Song He Qiu Zhiru Chen Jing Wang Yang Xu Zhanhong Liu Shuo Liu Zhiyuan Wang Xiangdong Zhu Kai Zhang Hai Lin Xingdong Zhang 
financially supported by the National Natural Science Foundation of China(32371399);the National Key Research and Development Program of China(2022YFC2409803);the Key Research and Development Program of Sichuan Province(23ZDYF2553)
Collagen,known for its excellent biocompatibility and biological properties,has limited in vivo maintenance duration after implantation,while hyaluronic acid faces challenges such as various complications and insuffic...
关键词：Collagen hydrogel Hyaluronic acid Cell phenotype Subcutaneous implantation Collagen regeneration 
An injectable magnesium-coordinated phosphate chitosan-based hydrogel loaded with vancomycin for antibacterial and osteogenesis in the treatment of osteomyelitis
《Regenerative Biomaterials》2024年第6期111-124,共14页Peng Zhang Tiehua Wang Junyu Qian Haotian Qin Peng Liu Ao Xiong Anjaneyulu Udduttula Deli Wang Hui Zeng Yingqi Chen 
supported by the Natural Science Foundation of China(no.82202664);Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research(no.ZDSYS20220606100602005);Guangdong Basic and Applied Basic Research Foundation(no.2023A1515012764,2021A1515220053,2022A1515220038);Sichuan Science and Technology Program(2023ZYD0115);Shenzhen Science and Technology Project(JCYJ20190809165805604,JCYJ20220818102815033,JCYJ20220531094214032),and Shenzhen High-level Hospital Construction Fund.
Microbial infections of bones,particularly after joint replacement surgery,are a common occurrence in clinical settings and often lead to osteomyelitis(OM).Unfortunately,current treatment approaches for OM are not sat...
关键词：injectable chitosan hydrogel vancomycin loading and release antibacterials property osteogenic promotive property osteomyelitis treatment 
Novel injectable adhesive hydrogel loaded with exosomes for holistic repair of hemophilic articular cartilage defect
《Bioactive Materials》2024年第12期85-111,共27页Qinfeng Yang Guihua Liu Guanghao Chen Guo Chen Keyu Chen Lei Fan Yuesheng Tu Jialan Chen Zhanjun Shi Chuan Chen Shubo Liu Geyang Deng Xiaoqian Deng Chunhan Sun Xiaoyang Li Shuofei Yang Shaowei Zheng Bin Chen 
supported by the National Natural Science Foundation of China Youth Fund(82202662);the Guangzhou Science and Technology Program(2023A04J2314);the National Natural Science Foundation of China(12,272,164);the China Postdoctoral Science Foundation(2023M741563);the Clinical Research Startup Program of Southern Medical University by High-level University Construction Funding of Guangdong Provincial Department of Education(LC2019ZD001);the Clinical Research Program of Nanfang Hospital,Southern Medical University(2019CR016);the Project of Drug Clinical Evaluate Research of Chinese Pharmaceutical Association(CPA-Z06-ZC-2021-004);the National Natural Science Foundation of China(82370497);the Medical Scientific Research Foundation of Guangdong(A2024366);Huizhou Science Technology Project Foundation(2022CZ010423);the Macao Science and Technology Development fund(FDCT(0012/2021/AMJ,003/2022/ALC,0092/2022/A2,0144/2022/A3));the Shenzhen-Hong Kong-Macao Science and Technology Fund(Category C:SGDX20220530111203020);the Foundation of Guangdong Basic and Applied Basic Research Foundation(2022A1515140151&2022A1515140189&2023A1515140045&2022A1515140071);the National Orthopaedics Key Clinical Specialty Construction Research Foundation of Huizhou Central People’s Hospital.
Hemophilic articular cartilage damage presents a significant challenge for surgeons,characterized by recurrent intraarticular bleeding,a severe inflammatory microenvironment,and limited self-repair capability of carti...
关键词：Hemophilic articular cartilage defect Adhesive hydrogel EXOSOMES ANTI-INFLAMMATION CHONDROGENESIS 
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