CHONDROGENESIS

作品数：47被引量：144H指数：7
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相关领域：医药卫生生物学更多>>
相关作者：丛锐军张长青郭尚春牛鑫汪泱更多>>
相关机构：无锡市人民医院上海市第十人民医院南方医科大学第三附属医院复旦大学更多>>
相关期刊：《Journal of Wuhan University of Technology(Materials Science)》《Cellular & Molecular Immunology》《Science China(Life Sciences)》《Frontiers in Biology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划高等学校学科创新引智计划广东省自然科学基金更多>>
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Temporal control in shell–core structured nanofilm for tracheal cartilage regeneration:synergistic optimization of anti-inflammation and chondrogenesis
《Regenerative Biomaterials》2025年第1期32-46,共15页Wen Zhao Fanglan Xu Yumei Shen Qifeng Ding Yifei Wang Leilei Liang Wufei Dai Yongbing Chen 
Funded by National Natural Science Foundation of China(82172076);Key Scientific Program of Jiangsu Provincial Health Commission(ZD2021033);Gusu Health Leading Talent Program of Suzhou(GSWS2021020);Discipline construction project of the Second Affiliated Hospital of Soochow University(XKTJXK202004);Scientific Program of Suzhou Municipal Health and Health Committee(LCZX202004);Project of Medical New Technology Assistance of the Second Affiliated Hospital of Soochow University(23ZL004 and 23ZL012).
Cartilage tissue engineering offers hope for tracheal cartilage defect repair.Establishing an anti-inflammatory microenvironment stands as a prerequisite for successful tracheal cartilage restoration,especially in imm...
关键词：temporal control core-shell structured NANOFILM tracheal cartilage regeneration ANTI-INFLAMMATION 
Novel injectable adhesive hydrogel loaded with exosomes for holistic repair of hemophilic articular cartilage defect
《Bioactive Materials》2024年第12期85-111,共27页Qinfeng Yang Guihua Liu Guanghao Chen Guo Chen Keyu Chen Lei Fan Yuesheng Tu Jialan Chen Zhanjun Shi Chuan Chen Shubo Liu Geyang Deng Xiaoqian Deng Chunhan Sun Xiaoyang Li Shuofei Yang Shaowei Zheng Bin Chen 
supported by the National Natural Science Foundation of China Youth Fund(82202662);the Guangzhou Science and Technology Program(2023A04J2314);the National Natural Science Foundation of China(12,272,164);the China Postdoctoral Science Foundation(2023M741563);the Clinical Research Startup Program of Southern Medical University by High-level University Construction Funding of Guangdong Provincial Department of Education(LC2019ZD001);the Clinical Research Program of Nanfang Hospital,Southern Medical University(2019CR016);the Project of Drug Clinical Evaluate Research of Chinese Pharmaceutical Association(CPA-Z06-ZC-2021-004);the National Natural Science Foundation of China(82370497);the Medical Scientific Research Foundation of Guangdong(A2024366);Huizhou Science Technology Project Foundation(2022CZ010423);the Macao Science and Technology Development fund(FDCT(0012/2021/AMJ,003/2022/ALC,0092/2022/A2,0144/2022/A3));the Shenzhen-Hong Kong-Macao Science and Technology Fund(Category C:SGDX20220530111203020);the Foundation of Guangdong Basic and Applied Basic Research Foundation(2022A1515140151&2022A1515140189&2023A1515140045&2022A1515140071);the National Orthopaedics Key Clinical Specialty Construction Research Foundation of Huizhou Central People’s Hospital.
Hemophilic articular cartilage damage presents a significant challenge for surgeons,characterized by recurrent intraarticular bleeding,a severe inflammatory microenvironment,and limited self-repair capability of carti...
关键词：Hemophilic articular cartilage defect Adhesive hydrogel EXOSOMES ANTI-INFLAMMATION CHONDROGENESIS 
Cartilage lacuna-biomimetic hydrogel microspheres endowed with integrated biological signal boost endogenous articular cartilage regeneration被引量：1
《Bioactive Materials》2024年第11期61-82,共22页Hao Li Tianyuan Zhao Zhiguo Yuan Tianze Gao Yongkang Yang Runmeng Li Qinyu Tian Peifu Tang Quanyi Guo Licheng Zhang 
Beijing Natural Science Foundation(L234024);Natural Science Foundation of China(82272481,323B2043);National Key R&D Program of China(2023YFB4605800).
Despite numerous studies on chondrogenesis,the repair of cartilage—particularly the reconstruction of cartilage lacunae through an all-in-one advanced drug delivery system remains limited.In this study,we developed a...
关键词：Microfluidic technology Hydrogel microsphere IMMUNOMODULATION CHONDROGENESIS Articular cartilage regeneration 
Promotion of osteochondral repair through immune microenvironment regulation and activation of endogenous chondrogenesis via the release of apoptotic vesicles from donor MSCs被引量：1
《Bioactive Materials》2024年第11期455-470,共16页Guangzhao Tian Han Yin Jinxuan Zheng Rongcheng Yu Zhengang Ding Zineng Yan Yiqi Tang Jiang Wu Chao Ning Xun Yuan Chenxi Liao Xiang Sui Zhe Zhao Shuyun Liu Weimin Guo Quanyi Guo 
Natural Science Foundation of Beijing Municipality(L234024);National Natural Science Foundation of China(82102552);Natural Science Foundation of Guangdong Province(2024A1515030295).
Utilizing transplanted human umbilical cord mesenchymal stem cells(HUMSCs)for cartilage defects yielded advanced tissue regeneration,but the underlying mechanism remain elucidated.Early after HUMSCs delivery to the de...
关键词：Apoptotic vesicles Cartilage regeneration Human umbilical cord mesenchymal stem cells Macrophage polarization Tissue engineering 
Adipose-derived mesenchymal stem cell-incorporated PLLA porous microspheres for cartilage regeneration
《Animal Models and Experimental Medicine》2024年第5期685-695,共11页Chang Gao Wenlong Yuan Dongcheng Wang Xin Zhang Tong Zhang Zhimin Zhou 
supported by grants from the CAMS Innovation Fund for Medical Sciences(2021-I2M-1-052);Tianjin Natural Science Foundation for Jingjinji Collaboration(23JCZXJC00240);Capital's Funds for Health Improvement and Research(CFH:2022-2-5072);Tianjin Hospital Fund for Science and Technology(Tjyy2109);the Open Fund of Tianjin Key Laboratory of Biomedical Materials(2022BMEKFKT002)。
Background:In facial plastic surgery,patients with nasal deformity are often treated by rib cartilage transplantation.In recent years,cartilage tissue engineering has developed as an alternative to complex surgery for...
关键词：centrifugation perfusion CHONDROGENESIS hyaluronic acid nasal fillers PLLA porous microspheres 
Promoting chondrogenesis by targeted delivery to the degenerating cartilage in early treatment of osteoarthritis被引量：1
《Bioactive Materials》2024年第10期624-633,共10页Yuxiang Fei Xiaojing Li Zhongyang Lv Zizheng Liu Ya Xie Jiaqi Chen Weitong Li Xiyu Liu Hu Guo Huan Liu Zhaofeng Zhang Xunhao Wang Jingjing Fan Chunqing Hu Xiaoyu Jin Ruiyang Jiang Nuo Xu Jiang Xia Yang Li Dongquan Shi 
supported by the National Natural Science Foundation of China(82325035,82172481,32271409,82071977,and 92059104);the Six Talent Peaks Project of Jiangsu Province(WSW-079);the 2018 High-Level Health Team of Zhuhai,the Innovation Project of National Orthopedics and Sports Medicine Rehabilitation Clinical Medical Research Center(2021-NCRC-CXJJ-ZH-16);the Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine Foundation of Guangdong Province(2023LSYS001).Fig.1a was created by Biorender.com.
Osteoarthritis(OA)is a highly incident total joint degenerative disease with cartilage degeneration as the primary pathogenesis.The cartilage matrix is mainly composed of collagen,a matrix protein with a hallmark trip...
关键词：Early-stage osteoarthritis Targeting therapy COLLAGEN Triple helix Albumin nanoparticle 
HIF-1α and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model
《Cellular & Molecular Immunology》2024年第7期770-786,共17页Akihiro Nakamura Sungsin Jo Sayaka Nakamura Mansi K.Aparnathi Shaghayegh Foroozan Boroojeni Mariia Korshko Ye-Soo Park Himanshi Gupta Sandra Vijayan Jason S.Rockel Mohit Kapoor Igor Jurisica Tae-Hwan Kim Nigil Haroon 
supported by grants to NH from the Canadian Institute of Health Research(CIHR)and Arthritis Society(Canada);AN is a recipient of a CIHR fellowship,Spondyloarthritis Research and Treatment Network(SPARTAN)fellowship,Spondyloarthritis Research Consortium of Canada(SPARCC)fellowship,Edward Christie Stevens fellowship;S.Fenwick Research fellowship,and Krembil Research Institute fellowship(Canada);IJ was supported in part by funding from the Natural Sciences Research Council(NSERC#203475);Canada Foundation for Innovation(CFI#225404,#30865);Ontario Research Fund(RDI#34876,RE010-020);IBM and Ian Lawson van Toch Fund.THK was supported by funding from the National Research Foundation(NRF)of Korea(NRF-2021R1A6A1A03038899);the Korea Healthy Industry Development Institute(HI23C0661).
The hallmarks of spondyloarthritis(SpA)are type 3 immunity-driven inflammation and new bone formation(NBF).Macrophage migration inhibitory factor(MIF)was found to be a key driver of the pathogenesis of SpA by amplifyi...
关键词：Endochondral ossification Hypoxia-inducible factor-1 alpha INTERLEUKIN-23 Macrophage migration inhibitory factor NEUTROPHIL SPONDYLOARTHRITIS 
Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor被引量：7
《Bioactive Materials》2024年第5期429-444,共16页Congyi Shen Jian Wang Guangfeng Li Shuyue Hao Yan Wu Peiran Song Yafei Han Mengmeng Li Guangchao Wang Ke Xu Hao Zhang Xiaoxiang Ren Yingying Jing Ru Yang Zhen Geng Jiacan Su 
supported by the National Key Research and Development Program of China(No.2022YFB3804300);Integrated Project of Major Research Plan of National Natural Science Foundation of China(92249303);Key Project of the National Natural Science Foundation of China(82230071);National Natural Science Foundation of China(32101084).
Osteoarthritis(OA),a common degenerative disease,is characterized by high disability and imposes substantial economic impacts on individuals and society.Current clinical treatments remain inadequate for effectively ma...
关键词：Silk fibroin-DNA hydrogel MICROSPHERE CHONDROGENESIS Cartilage organoid Cartilage repair 
Involvement of Sox9a in chondrogenesis and gonadal development in teleost Nile tilapia(Oreochromis niloticus)被引量：1
《Zoological Research》2023年第4期729-731,共3页Xiao-Yan Li Yao-Hao Tang Wan-Yue Deng Yan Zheng Ling-Song Wang Xue He Qing-Ping Xie Yue-Qin Li Li Deng De-Shou Wang Ling Wei 
supported by the National Key Research and Development Program of China(2022YFD1201600);National Natural Science Foundation of China(31861123001,31302170,and 31772831);Chongqing Science and Technology Bureau(CSTB2022NSCQ-MSX1608 and cstc2021ycjh-bgzxm0024);Chongqing Fishery Technology Innovation Union(2023)。
DEAR EDITOR,Sox9 is a member of the Sry-related high-mobility group box(Sox)transcription factor family in animals.In teleost fish,Sox9 undergoes duplication to generate two duplicates,namely Sox9a and Sox9b.However,t...
关键词：CRISPR/Cas9 IMPAIRED SOX9 
Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field被引量：5
《Bioactive Materials》2023年第4期312-324,共13页Yucong Li Linlong Li Ye Li Lu Feng Bin Wang Ming Wang Haixing Wang Meiling Zhu Yongkang Yang Erik IWaldorff Nianli Zhang Ingmar Viohl Sien Lin Liming Bian Wayne Yuk-Wai Lee Gang Li 
This work was partially supported by grants from University Grants Committee,Research Grants Council of the Hong Kong Special Administrative Region,China(14108720,14121721,14202920,T13-402/17-N and AoE/M-402/20).
Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged cartilage.Hydrogel is widely used because it could provide rapid defect filling and proper structure supp...
关键词：Supramolecular hydrogels Pulsed electromagnetic field Cartilage tissue engineering Mesenchymal stem cells CHONDROGENESIS 
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