supported by grants to NH from the Canadian Institute of Health Research(CIHR)and Arthritis Society(Canada);AN is a recipient of a CIHR fellowship,Spondyloarthritis Research and Treatment Network(SPARTAN)fellowship,Spondyloarthritis Research Consortium of Canada(SPARCC)fellowship,Edward Christie Stevens fellowship;S.Fenwick Research fellowship,and Krembil Research Institute fellowship(Canada);IJ was supported in part by funding from the Natural Sciences Research Council(NSERC#203475);Canada Foundation for Innovation(CFI#225404,#30865);Ontario Research Fund(RDI#34876,RE010-020);IBM and Ian Lawson van Toch Fund.THK was supported by funding from the National Research Foundation(NRF)of Korea(NRF-2021R1A6A1A03038899);the Korea Healthy Industry Development Institute(HI23C0661).
The hallmarks of spondyloarthritis(SpA)are type 3 immunity-driven inflammation and new bone formation(NBF).Macrophage migration inhibitory factor(MIF)was found to be a key driver of the pathogenesis of SpA by amplifyi...
BACKGROUND Remarkable progress over the last decade has equipped clinicians with many options in the treatment of inflammatory bowel disease.Clinicians now have the unique opportunity to provide individualized treatme...
Shanxi Provincial Natural Science Foundation Project(202203021211083);College Science and Technology Innovation Project of Shanxi Provincial Education Department(2020L044);Graduate Innovation Program of Shanxi University of Traditional Chinese Medicine(2021CX035)。
Objective:To explore the intervention effect of medicine combined with mild moxibustion on immune factor and Na/I symporter(NIS)in hypothyroidism rat model.Methods:The model was successfully made by intragastric admin...
This study was supported by grant from the National Key R&D Program of China(2017YFC0114303);grant from the Natural Science Foundation of Science and Technology Commission of Shanghai Municipality(20ZR1412300);grant from the Medical Innovation Research Project of the Science and Technology Commission of Shanghai Municipality(No.20Y11905000);grants from the AoXiang Project of the Shanghai Anti-Cancer Association(SACA-AX201908 and SACA-AX202005);All these study sponsors have no roles in the study design,collection,analysis,and interpretation of data.
Individualized treatment of prostate cancer depends on an accurate stratification of patients who are sensitive to various treatments.Interleukin-23(IL-23)was reported to play a significant role in prostate cancer.Her...
Hepatitis B virus reactivation(HBVr)can occur in patients treated with immunosuppressive medications.Risk stratification for HBVr based on hepatitis B virus(HBV)serology and viral load is an important strategy to dete...
Objective:To observe the presence of toll-like receptor 4(TLR4)gene polymorphism in the venous blood in patients with sepsis,meanwhile,to observe the expression and the diagnostic value of TLR4 mRNA,interferon-(IFN-),...
The Science and Technology Bureau of Wuhan,China(No.2015061701011646);the Key Projects of the Hubei Provincial Education Department(No.D20112001)。
OBJECTIVE:To investigate the mechanism by which Daifan San(DFS)prevents and treats primary biliary cirrhosis(PBC)via the forkhead box P3(FoxP3)and interleukin(IL)-23/IL-17A signaling pathways.METHODS:Ninety C57BL/6 mi...
Hubei Natural Science Foundation of China(2015CFB701).
Objective: To investigate the effect of interleukin-23 (IL-23) on myocardial ischemia-reperfusion (I/R) injury.Methods: Male Sprague-Dawley rats were randomly assigned into sham operated control (SO) group, ischemia a...