Biomedical application of materials for external auditory canal: History,challenges, and clinical prospects  

作　　者：Yang Xu Zhongwu Bei Mei Li Lin Ye Bingyang Chu Yu Zhao Zhiyong Qian 

机构地区：[1]Department of Otorhinolaryngology-Head&Neck Surgery,West China Hospital,Sichuan University,Chengdu,Sichuan,China [2]Department of Biotherapy,Cancer Center and State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu,Sichuan,China [3]Department of Ophthalmology,West China Hospital,Sichuan University,Chengdu,Sichuan,China

出　　处：《Bioactive Materials》2024年第9期317-335,共19页生物活性材料（英文）

基　　金：funded by National Natural Science Foundation of China(Grant No.U21A20417,31930067);"1⋅3⋅5"Project for Disciplines of Excellence,West China Hospital,Sichuan University(Grant No.ZYGD18002).

摘　　要：Biomaterials play an integral role in treatment of external auditory canal (EAC) diseases. Regarding the specialanatomic structure and physiological characteristics of EAC, careful selection of applicable biomaterials wasessential step towards effective management of EAC conditions. The bioactive materials can provide reasonablebiocompatibility, reduce risk of host pro-inflammatory response and immune rejection, and promote the healingprocess. In therapeutic procedure, biomaterials were employed for covering or packing the wound, protection ofthe damaged tissue, and maintaining of normal structures and functions of the EAC. Therefore, understandingand application of biomaterials was key to obtaining great rehabilitation in therapy of EAC diseases. In clinicalpractice, biomaterials were recognized as an important part in the treatment of different EAC diseases. Thechoice of biomaterials was distinct according to the requirements of various diseases. As a result, awareness ofproperty regarding different biomaterials was fundamental for appropriate selection of therapeutic substances indifferent EAC diseases. In this review, we firstly introduced the characteristics of EAC structures and physiology,and EAC pathologies were summarized secondarily. From the viewpoint of biomaterials, the different materialsapplied to individual diseases were outlined in categories. Besides, the underlying future of therapeutic EACbiomaterials was discussed.

关 键 词：BIOMATERIALS Post-operative stenosis External auditory canal Acquired aural atresia Clinical transformation 

分 类 号：R318[医药卫生—生物医学工程]