Mechanically skin-like and water-resistant self-healing bioelastomer for high-tension wound healing  

作　　者：Jinyi Huang Hongying Chen Zenghui Jia Xingqi Song Sinan Wang Baoshuai Bai Jian Wang Junfeng Zhang Guangdong Zhou Dong Lei 

机构地区：[1]Department of Plastic and Reconstructive Surgery,Department of Cardiology,Shanghai Key Lab of Tissue Engineering,Shanghai 9th People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200011,PR China [2]Research Institute of Plastic Surgery,Shandong Second Medical University,Weifang,Shandong,261053,PR China

出　　处：《Bioactive Materials》2024年第9期443-455,共13页生物活性材料（英文）

基　　金：supported by the National Key Research and Development Program of China(2022YFA1207500);the National Key Research and Development Program of China(2022YFC2409803);Biomaterials and Regenerative Medicine Institute Cooperative Research Project of Shanghai Jiaotong University School of Medicine(2022LHA07);the National Natural Science Foundation of China(82102211);Experimental Animal Research Project of Shanghai Science and Technology Commission(No.22140901200);Shanghai Municipal Key Clinical Specialty(shslczdzk06601).

摘　　要：The biomedical application of self-healing materials in wet or(under)water environments is quite challenging because the insulation and dissociation effects of water molecules significantly reduce the reconstruction of material–interface interactions.Rapid closure with uniform tension of high-tension wounds is often difficult,leading to further deterioration and scarring.Herein,a new type of thermosetting water-resistant self-healing bioelastomer(WRSHE)was designed by synergistically incorporating a stable polyglycerol sebacate(PGS)covalent crosslinking network and triple hybrid dynamic networks consisting of reversible disulfide metathesis(SS),and dimethylglyoxime urethane(Dou)and hydrogen bonds.And a resveratrol-loaded WRSHE(Res@WRSHE)was developed by a swelling,absorption,and crosslinked network locking strategy.WRSHEs exhibited skin-like mechanical properties in terms of nonlinear modulus behavior,biomimetic softness,high stretchability,and good elasticity,and they also achieved ultrafast and highly efficient self-healing in various liquid environments.For wound-healing applications of high-tension full-thickness skin defects,the convenient surface assembly by self-healing of WRSHEs provides uniform contraction stress to facilitate tight closure.Moreover,Res@WRSHEs gradually release resveratrol,which helps inflammatory response reduction,promotes blood vessel regeneration,and accelerates wound repair.

关 键 词：Underwater self-healing Dynamic bonds BIOELASTOMER High-tension wounds RESVERATROL 

分 类 号：O63[理学—高分子化学]