A mussel-inspired,antibacterial,antioxidant,injectable composite hydrogel for the sustain delivery of salvianolic acid B for the treatment of frozen shoulder  

作　　者：Yan Yan Xinhao Li Chen Chen Dedong Cui Zhuo Wang Ming Li Yi Long Jinming Zhang Cheng Li Zhiling Wang Chuanhai Zhou Zeyu Yao Dan Wang Jingyi Hou Rui Yang 

机构地区：[1]Department of Orthopedics,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,510000,China [2]Department of Geriatric Dentistry,NMPA Key Laboratory for Dental Materials National Engineering Laboratory for Digital and Material Technology of Stomatology,Peking University School and Hospital of Stomatology,Beijing,100081,China [3]School of Biomedical Science,The Chinese University of Hong Kong,Hong Kong,999077,China

出　　处：《Bioactive Materials》2024年第10期396-416,共21页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(NO.81972067,82002342);the Fundamental Research Funds for the Central Universities,Sun Yatsen University(NO.2020004);Yan Yan and Xinhao Li contributed equally to this work.

摘　　要：Frozen shoulder(FS)manifests as progressively worsening pain and a reduction in shoulder range of motion(ROM).Salvianolic acid B(SaB)is recently expected to be used in the treatment of fibrosis diseases including FS.We firstly demonstrate that SaB can effectively hinder the progression of oxidative stress,inflammation,and pathological fibrosis within the synovial tissue in FS,potentially leading to the reduction or reversal of capsule fibrosis and joint stiffness.For further clinical application,we design and synthesize a novel,superior,antioxidant and antibacterial CSMA-PBA/OD-DA(CPDA)hydrogel for the delivery of SaB.In vitro experiments demonstrate that the CPDA hydrogel exhibits excellent biocompatibility and rheological properties,rendering it suitable for intra-articular injections.Upon injection into the contracted joint cavity of FS model rat,the SaBCPDA hydrogel accelerate the recovery of ROM and exhibit superior anti-fibrosis effect,presenting the promise for the treatment of FS in vivo.

关 键 词：Frozen shoulder HYDROGEL Salvianolic acid b FIBROSIS NF-κB/IL-6 signaling pathway 

分 类 号：TQ427.26[化学工程]