Developing fibrin-based biomaterials/scaffolds in tissue engineering  

作　　者：Songjie Li Xin Dan Han Chen Tong Li Bo Liu Yikun Ju Yang Li Lanjie Lei Xing Fan 

机构地区：[1]Department of Plastic and Reconstructive Surgery,Xijing Hospital,Fourth Military Medical University,Xi’an,710032,China [2]Department of Plastic and Aesthetic(Burn)Surgery,The Second Xiangya Hospital,Central South University,Changsh1,410011,China [3]Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province,Institute of Translational Medicine,Zhejiang Shuren University,Hangzhou,310015,China

出　　处：《Bioactive Materials》2024年第10期597-623,共27页生物活性材料（英文）

基　　金：supported by Education Department of Shaanxi Provincial Government(No.YJSZG2023134);Nanjing Medical University Fan Daiming Research Funds for Holistic Integrative Medicine.

摘　　要：Tissue engineering technology has advanced rapidly in recent years, offering opportunities to construct biologicallyactive tissues or organ substitutes to repair or even enhance the functions of diseased tissues and organs.Tissue-engineered scaffolds rebuild the extracellular microenvironment by mimicking the extracellular matrix.Fibrin-based scaffolds possess numerous advantages, including hemostasis, high biocompatibility, and gooddegradability. Fibrin scaffolds provide an initial matrix that facilitates cell migration, differentiation, proliferation,and adhesion, and also play a critical role in cell-matrix interactions. Fibrin scaffolds are now widelyrecognized as a key component in tissue engineering, where they can facilitate tissue and organ defect repair.This review introduces the properties of fibrin, including its composition, structure, and biology. In addition, themodification and cross-linking modes of fibrin are discussed, along with various forms commonly used in tissueengineering. We also describe the biofunctionalization of fibrin. This review provides a detailed overview of theuse and applications of fibrin in skin, bone, and nervous tissues, and provides novel insights into future researchdirections for clinical treatment.

关 键 词：FIBRIN SCAFFOLD Tissue engineering Tissue repair 

分 类 号：R318[医药卫生—生物医学工程]