龙须菜渣纤维素/纳米纤维素及其水凝胶的制备和性能研究  

Preparation and property study of cellulose/nanocellulose and its hydrogel from Gracilaria lemaneiformis residue

作　　者：吴靖娜 林泽烨 苏筱 张任翔 陈晓婷[3] 潘南[3] WU Jingna;LIN Zeye;SU Xiao;ZHANG Renxiang;CHEN Xiaoting;PAN Nan(Fujian Universities and Colleges Engineering Research Center of Marine Biopharmaceutical Resources,Xiamen Medical College,Xiamen 361023,China;Xiamen Key Laboratory of Marine Medicinal Natural Products Resources,Xiamen Medical College,Xiamen 361023,China;Fisheries Research Institute of Fujian,Xiamen 361013,China)

机构地区：[1]厦门医学院海洋生物医药资源福建省高校工程研究中心,福建厦门361023 [2]厦门医学院厦门市海洋药用天然产物资源重点实验室,福建厦门361023 [3]福建省水产研究所,福建厦门361013

出　　处：《轻工学报》2024年第6期49-56,共8页Journal of Light Industry

基　　金：国家自然青年科学基金项目(3230161013)。

摘　　要：以龙须菜(Gracilaria lemaneiformis)渣为主要原料制备龙须菜纤维素(GLC)和纳米纤维素(NGLC),并将其溶解于离子液体1-乙基-3-甲基咪唑醋酸盐中制备龙须菜纤维素水凝胶(GLC-H)和纳米纤维素水凝胶(NGLC-H),通过傅里叶变换红外光谱仪、X射线衍射仪、差示量热扫描仪等对其结构、形貌、热稳定性和流变性能进行表征分析,并考查GLC-H和NGLC-H的溶胀性能、释药性能和抑菌性能。结果表明:GLC、NGLC、GLC-H和NGLC-H的制备是一个非衍生化过程;GLC和NGLC在离子液体体系中成功交联形成孔道结构,且NGLC-H较GLC-H的三维网状结构更明显;GLC、NGLC形成水凝胶后,晶型从Ⅰ型转变为Ⅱ型,热稳定性有所降低;NGLC-H的吸水性能明显高于GLC-H,溶胀平衡时,二者的溶胀率分别为560.3%和175.3%;当药物释放时间为30 min时,载药GLC-H和载药NGLC-H的药物释放量均达到最大值,分别为87.22%和73.33%,且在整个载药过程中,后者的药物释放量均低于前者;载药GLC-H和载药NGLC-H均具有一定的抑菌作用,且两者效果相当。Gracilaria lemaneiformis residue was used as a raw material to prepare Gracilaria lemaneiformis cellulose(GLC)and nanocellulose(NGLC),which were then used to develop cellulose(GLC-H)and nanocellulose hydrogels(NGLC-H)by dissolving them in ionic liquid 1-ethyl-3-methylimidazole acetate.Fourier transform infrared spectroscopy,X-ray diffraction,and differential scanning calorimetry were employed to characterize and analyze the structure,morphology,thermal stability,and rheological properties.Additionally,the swelling properties,drug release performance,and antibacterial properties of GLC-H and NGLC-H were investigated.The results indicated that the preparation of GLC,NGLC,GLC-H,and NGLC-H was a non-derivatization process.GLC and NGLC successfully crosslinked to form a porous structure in the ionic liquid system,with the three-dimensional network structure of NGLC-H being more pronounced than that of GLC-H.After forming hydrogels,the crystalline form of GLC and NGLC changed from type Ⅰ to type Ⅱ,and their thermal stability decreased.The water absorption performance of NGLC-H was significantly higher than that of GLC-H,with swelling rates of 560.3% and 175.3% respectively at equilibrium.When the drug release time was 30 minutes,the maximum drug release amounts from drug-loaded GLC-H and drug-loaded NGLC-H were 87.22% and 73.33% respectively.Throughout the drug-loading process,the drug release amount from NGLC-H was consistently lower than that from GLC-H.Both drug-loaded GLC-H and drug-loaded NGLC-H exhibited certain antibacterial effects,with comparable efficacy.

关 键 词：龙须菜渣 纤维素 纳米纤维素 水凝胶 溶胀性能 释药性能 抑菌性能 

分 类 号：TS254.9[轻工技术与工程—水产品加工及贮藏工程]