自噬介导肝细胞癌耐药的相关机制  

The mechanism of autophagy inducing drug resistance of hepatocellular carcinoma

作　　者：张润兵 史婷婷 伍杨 张久聪 郑晓凤[3] ZHANG Runbing;SHI Tingting;WU Yang;ZHANG Jiucong;ZHENG Xiaofeng(The First Clinical College of Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Gastroenterology,The 940 Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050,China;Department of Gastroenterology,The Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]中国人民解放军联勤保障部队第九四〇医院消化内科,兰州730050 [3]兰州大学第二医院消化内科,兰州730030

出　　处：《临床肝胆病杂志》2024年第11期2315-2319,共5页Journal of Clinical Hepatology

基　　金：中央高校优秀青年团队培育项目(1001451201);甘肃省自然科学基金青年项目(22JR5RA1012)。

摘　　要：肝细胞癌(HCC)治疗抵抗是制约其疗效的重要因素。自噬是一种多步骤、多靶点的过程,与肿瘤细胞的增殖和凋亡密切相关。同时,自噬与肿瘤治疗抗性之间也存在显著串扰。因此,自噬可能是肿瘤细胞在临床干预后阻碍细胞死亡的关键因素之一。转化生长因子-β、上皮间充质转化、长链非编码RNA是导致HCC耐药的重要因素。本文从转化生长因子-β、上皮间充质转化及长链非编码RNA这三个角度,探讨其介导复杂的分子网络诱导自噬的发生而影响HCC耐药性的可能机制,为提高HCC治疗敏感性探索新的思路。Treatment resistance of hepatocellular carcinoma(HCC)is an important factor restricting its treatment outcome.Autophagy is a process involving multiple steps and targets and is closely associated with the proliferation and apoptosis of tumor cells.At the same time,there is significant crosstalk between autophagy and tumor treatment resistance.Therefore,autophagy may be one of the key factors hindering tumor cell death after medical intervention.Transforming growth factor-β(TGF-β),epithelialmesenchymal transition(EMT),and long non-coding RNA(lncRNA)are important factors leading to drug resistance of HCC.This article discusses the possible mechanism of TGF-β,EMT,and lncRNA mediating complex molecular networks and inducing drug resistance of HCC,in order to provide new ideas for improving the sensitivity of HCC treatment.

关 键 词：癌 肝细胞 自噬 抗药性 肿瘤 

分 类 号：R735.7[医药卫生—肿瘤]