铜死亡的发生机制及在肝脏疾病中的作用  

Mechanism of cuproptosis and its role in liver diseases

作　　者：朱明强 谢星 廖启成 何晓 丁佑铭[2] 王小华 ZHU Mingqiang;XIE Xing;LIAO Qicheng;HE Xiao;DING Youming;WANG Xiaohua(Department of Hepatobiliary Surgery,The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000,China;Department of Hepatobiliary Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]赣南医科大学第一附属医院肝胆外科,江西赣州341000 [2]武汉大学人民医院肝胆外科,武汉430060

出　　处：《临床肝胆病杂志》2024年第11期2332-2337,共6页Journal of Clinical Hepatology

基　　金：国家重点研发计划(2022YFC2407304)。

摘　　要：铜死亡是依赖于细胞内铜积累触发线粒体脂酰化蛋白的聚集和铁硫簇蛋白不稳定的新型细胞死亡方式,其作用机制不同于自噬、铁死亡、细胞焦亡、坏死性凋亡等。铜死亡与肝癌发生及抗肿瘤药物耐药、遗传性肝脏疾病、非酒精性脂肪性肝病、病毒性肝炎和肝硬化等多种肝脏疾病的进展密切相关。本文总结了铜死亡的发生机制及在肝脏疾病中的作用和进展,旨在为肝脏疾病的进一步研究与治疗提供参考。Cuproptosis is a new type of cell death that depends on intracellular copper accumulation to trigger the aggregation of mitochondrial lipoacylated protein and the degradation of iron-sulfur cluster protein,with a different mechanism of action from autophagy,ferroptosis,pyroptosis,and necroptosis.Cuproptosis is closely association with the development of liver cancer and resistance to antitumor drugs,as well as the progression of various liver diseases such as hereditary liver diseases,nonalcoholic fatty liver disease,viral hepatitis,and liver cirrhosis.This article summarizes the mechanism of cuproptosis and its role in liver diseases,in order to provide a reference for further research and treatment of liver diseases.

关 键 词：铜 细胞死亡 肝疾病 

分 类 号：R575[医药卫生—消化系统]