不同子宫内膜准备方案多囊卵巢综合征患者冻融单囊胚移植临床结局的比较  

Comparison of outcomes of polycystic ovary syndrome patients with monoblastocyst frozen-thawed embryo transfer using different endometrial preparation

作　　者：曹梦依 俎若雯 杨宸 郑威 吴静 邝义会 李梦娜 吴欢 冉诗雨 申冉 韩静宜 管一春[1] CAO Mengyi;ZU Ruowen;YANG Chen;ZHENG Wei;WU Jing;KUANG Yihui;LI Mengna;WU Huan;RAN Shiyu;SHEN Ran;HAN Jingyi;GUAN Yichun(Center for Reproductive Medicine,the Third Affiliated Hospital,Zhengzhou University,Zhengzhou 450052)

机构地区：[1]郑州大学第三附属医院生殖医学中心,郑州450052

出　　处：《郑州大学学报（医学版）》2024年第6期812-816,共5页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家重点研发计划重点专项(2021YFC2700602);河南省中青年卫生健康科技创新领军人才培养项目(YXKC2021020);河南省医学科技攻关省部共建重点项目(SBGJ202102180)。

摘　　要：目的:探讨子宫内膜准备方案对多囊卵巢综合征(PCOS)患者单囊胚冻融胚胎移植(FET)临床结局的影响。方法:收集2016年1月至2023年9月于郑州大学第三附属医院行体外受精/卵泡浆内单精子显微注射-胚胎移植单囊胚FET的PCOS患者1859例的临床资料,其中采用刺激周期方案354周期,人工周期方案1402个周期和降调+人工周期方案103个周期。比较3组的临床结局。结果:刺激周期组剖宫产率(65.2%)低于人工周期组(76.9%)及降调+人工周期组(89.8%)(P<0.05)。Logistic回归结果显示,校正双方年龄、女方BMI及不孕年限等混杂因素后,人工周期及降调+人工周期方案剖宫产风险较刺激周期方案增加,OR(95%CI)分别为1.707(1.211~2.405)、4.839(1.825~12.826)。结论:3种子宫内膜准备方案对PCOS患者单囊胚FET临床结局无明显影响,刺激周期方案的剖宫产风险更低。Aim:To compare the outcomes of polycystic ovary syndrome(PCOS)patients with monoblastocyst frozen-thawed embryo transfer(FET)using different endometrial preparation.Methods:Data of 1859 cycles of PCOS patients from the Third Affiliated Hospital of Zhengzhou University from January 2016 to September 2023 were collected,and all the cycles were monoblastocyst FET with in vitro fertilization/intracytoplasmic sperm injection.Among the 1859 cycles,354 cycles used stimulation cycle scheme,1402 cycles used artificial cycle scheme,and 103 cycles used down-modulation+artificial cycle scheme.The outcomes of the 3 groups were compared.Results:The cesarean section rate of stimulation cycle group(65.2%)was lower than those of artificial cycle group(76.9%)and down-modulation+artificial cycle group(89.8%)(P<0.05).The results of Logistic regression showed that,after adjusting for confounding factors such as age of parents,the woman′s BMI,and duration of infertility,the risks of cesarean section in the artificial cycle and down-modulation+artificial cycle schemes were higher than stimulated cycle scheme,with OR(95%CI)being 1.707(1.211-2.405)and 4.839(1.825-12.826),respectively.Conclusion:The three endometrial preparation schemes has no significant effect on clinical outcomes of monoblastocyst FET of PCOS patients,and stimulation cycle scheme could reduce risk of cesarean section.

关 键 词：多囊卵巢综合征 冻融胚胎移植 子宫内膜准备 

分 类 号：R783.5[医药卫生—口腔医学]