A型肉毒毒素在口腔疾病治疗中的研究进展  

Research progress of botulinum toxin A in the therapeutic applications of oral diseases

作　　者：李鑫 冯筱妍 沈奕洋 林军[1] Li Xin;Feng Xiaoyan;Shen Yiyang;Lin Jun(Department of Stomatology,The First Affiliated Hospital of Zhejiang University School of Medicine,School of Stomatology,and Key Laboratory of Oral Biomedical Research of Zhejiang Province,Hangzhou310003,China)

机构地区：[1]浙江大学医学院附属第一医院口腔科·口腔医学院、浙江省口腔生物医学研究重点实验室,杭州310003

出　　处：《中华口腔医学杂志》2024年第11期1168-1173,共6页Chinese Journal of Stomatology

基　　金：国家自然科学基金(81970978)。

摘　　要：A型肉毒毒素(BTX-A)是由肉毒杆菌产生的一种效力强大的神经毒素,通过抑制神经-肌肉/腺体接头处乙酰胆碱的释放,从而解除肌肉痉挛或抑制腺体分泌。此外,BTX-A还能在感觉反馈回路中发挥作用,具有缓解疼痛的作用。目前,口腔医师对BTX-A在口腔颌面部的美容性应用更多关注,而对其非美容性应用的认识仍然不足。尽管BTX-A在口腔疾病治疗中的具体分子机制尚未完全阐明,但随着循证医学的发展,越来越多的临床证据开始支持BTX-A在口腔疾病治疗中的有效性。本文对BTX-A的主要分子机制、在口腔疾病治疗中的国内外最新临床研究进展、临床禁忌证和不良反应等做简要综述,为相关口腔疾病的治疗提供新思路。Botulinum toxin A(BTX-A)is a powerful neurotoxin produced by Clostridium botulinum,which can relieve muscle spasm or limit gland secretion by inhibiting the release of acetylcholine at the neuromuscular/glandular junction.In addition,BTX-A can also play a role in the sensory feedback loop,which can ease pain.Currently,dentists are paying more attention to the cosmetic applications of BTX-A in the oral and maxillofacial region,while their understanding of BTX-A′s non-cosmetic applications is still insufficient.Although the specific molecular mechanism of BTX-A in oral diseases has not been fully clarified,with the development of evidence-based medicine,more and more clinical evidence has began to support the effectiveness of BTX-A in the therapeutic applications of oral diseases.This article will briefly review the main molecular mechanisms of BTX-A,the latest clinical research progress of BTX-A at home and abroad in the treatment of oral diseases,clinical contraindications and adverse reactions of BTX-A,providing a new idea for the treatment of oral diseases.

关 键 词：肉毒毒素类 A型肉毒毒素 口腔疾病 治疗性应用 

分 类 号：R78[医药卫生—口腔医学]