从易感性到预后:细胞色素P450家族在肝细胞癌中的多面作用  

From susceptibility to prognosis:the multifaceted role of the cytochrome p450 family in hepatocellular carcinoma

作　　者：洪生杰 张广权 李瑞曦[1] 何勇飞 吴芬芳[1] 史宪杰 Hong Shengjie;Zhang Guangquan;Li Ruixi;He Yongfei;Wu Fenfang;Shi Xianjie(Department of Hepatobiliary and Pancreas Surgery,Eighth Affiliated Hospital of Sun Yat-sen University,Shenzhen 518000,China)

机构地区：[1]中山大学附属第八医院肝胆胰外科,深圳518000

出　　处：《肝癌电子杂志》2024年第3期58-63,共6页Electronic Journal of Liver Tumor

基　　金：深圳市基础研究资助项目(JCYJ20220530144404010,JCYJ20220530144404011);福田区卫生健康系统科研项目资助项目(FTWS2023037);中国博士后科学基金项目(2023M744020);深圳市基础研究重点项目(JCYJ20220818103407016);广东省省企联合基金面上项目(2023A1515220186);中山大学附属第八医院优秀医学创新人才项目(YXYXCXRC202414)。

摘　　要：细胞色素P450(CYP450)家族是一类参与外源性和内源性化合物代谢的重要酶。越来越多的证据表明CYP450家族在肝细胞癌(HCC)的发生、发展和预后中发挥着关键作用。CYP450家族基因多态性可影响个体对致癌物的敏感度和代谢能力,与HCC的发生风险密切相关。此外,CYP450家族基因表达失调参与HCC的进展,其作用机制涉及活性氧水平、DNA损伤、细胞增殖、细胞侵袭和细胞凋亡等多个方面。CYP450家族基因表达水平还与HCC患者的预后密切相关,有望成为判断预后的重要指标。总之,深入理解CYP450家族在HCC发生、发展和预后中的作用,对于阐明HCC的分子机制、制订个体化预防和治疗策略具有重要意义。未来研究应进一步探究CYP450家族基因多态性和表达失调的分子机制,建立相应的风险预测和预后评估模型,并重视药物对CYP450家族的调控作用,以期为HCC的防治提供新的策略和靶点。The cytochrome P450(CYP450)family is a group of enzymes that play a crucial role in the metabolism of exogenous and endogenous compounds.Growing evidence suggests that the CYP450 family is pivotal in the occurrence,progression,and prognosis of hepatocellular carcinoma(HCC).Polymorphisms in CYP450 family genes can influence an individual's susceptibility to carcinogens and metabolic capacity,closely associated with the risk of HCC.Furthermore,dysregulation of CYP450 family genes is involved in HCC progression,with mechanisms encompassing reactive oxygen species levels,DNA damage,cell proliferation,invasion,and apoptosis.The expression levels of CYP450 family genes are also intimately linked to the prognosis of HCC patients,showing promise as essential indicators for prognostic assessment.In conclusion,a deep understanding of the role of the CYP450 family in the occurrence,progression,and prognosis of HCC is of great significance for elucidating the molecular mechanisms of HCC and developing individualized prevention and treatment strategies.Future research should further investigate the molecular mechanisms underlying the polymorphisms and dysregulation of CYP450 family genes,establish corresponding risk prediction and prognostic evaluation models,and emphasize the regulatory effects of drugs on the CYP450 family,aiming to provide new strategies and targets for the prevention and treatment of HCC.

关 键 词：细胞色素P450 肝细胞癌 基因多态性 代谢 预后 

分 类 号：R735.7[医药卫生—肿瘤]