双酚AF毒性及其机制的研究进展  

Research progress on the toxicity and mechanism of BPAF

作　　者：邵一鸣 洪新宇[1] SHAO Yiming;HONG Xinyu(Chemical Toxicity Identification Institute of Shanghai Municipal Center for Disease Control and Prevention,Key Laboratory of Environmental Health Impact Assessment for New Pollutants in National Environmental Protection,Shanghai200050,China)

机构地区：[1]上海市疾病预防控制中心化学品毒性检定所,国家环境保护新型污染物环境健康影响评价重点实验室,上海200050

出　　处：《中国食品卫生杂志》2024年第8期976-981,共6页Chinese Journal of Food Hygiene

基　　金：上海市卫生健康委员会科研项目计划(20224Y0329);上海市自然科学基金(23ZR1459600)。

摘　　要：双酚AF(BPAF)是一种双酚A(BPA)类似物,随着欧盟颁布在多种场所中禁用或限用BPA的规定,大量BPA类似物随之出现,其中BPAF因其韧性优良等特点应用较广。本文将从生殖、发育、内分泌、免疫、神经等方面对BPAF的毒理学作用及机制研究进行梳理,并对存在的问题进行总结,为后续研究和管理提供思路和依据。Bisphenol AF(BPAF)is a kind of bisphenol A analogue.With the promulgation of the EU to ban or restricting the use of BPA in a variety of places,a large number of BPA analogues have emerged.The production of BPAF is increasing due to its excellent toughness and other characteristics.Based on a large number of BPAF laboratory studies,this paper sorts out the toxicological data of BPAF from the aspects of reproductive toxicity,developmental toxicity,endocrine toxicity,immunotoxicity,and neurotoxicity,summarizes the toxic effects of BPAF,provides ideas for scientific research,and provides policy basis for scientific management.

关 键 词：双酚AF 双酚A类似物 雌激素受体 BPAF毒性 

分 类 号：R155[医药卫生—营养与食品卫生学]