氟的雄性生殖毒性研究进展  

Research advance on reproductive toxicity of fluoride in males

作　　者：郎哲涛 魏冉 王二辉 LANG Zhetao;WEI Ran;WANG Erhui(School of Medicine,Shaoxing University,ZhejiangShaoxing312000,China;Key Laboratory of Reproductive Health Diseases Research and Translation(Hainan Medical University),Ministry of Education,HainanHaikou571199,China)

机构地区：[1]绍兴文理学院医学院,浙江绍兴312000 [2]海南医学院生殖健康及相关疾病研究与转化教育部重点实验室,海南海口571199

出　　处：《中国食品卫生杂志》2024年第8期989-994,共6页Chinese Journal of Food Hygiene

基　　金：海南省人类生殖与遗传重点实验室开放课题(SZLAB202307);绍兴文理学院博士启动基金(20210036)。

摘　　要：氟是一种在自然界广泛分布的元素,是人体必需的微量元素,同时也被认为是一种普遍的环境污染物。近年来许多研究表明,氟具有雄性生殖毒性,表现为睾丸和附睾结构异常、生殖激素分泌异常、睾丸抗氧化酶活性减弱、精子质量下降等。本文就氟对雄性生殖系统的毒性及相关调控机制进行综述,以期为氟诱导的雄性生殖损伤防治提供依据。Fluorine is an element widely distributed in the environment,an essential trace element for human body,and also considered as a common environmental pollutant.In recent years,many studies have shown that fluoride exerts male reproductive toxicity,which is characterized by abnormal testicular and epididymis structure,decreased sperm quality,abnormal secretion of reproductive hormones,and weakened antioxidant enzyme activity in testis.In this paper,the toxicity of fluoride exposure to male reproductive system and related regulatory mechanisms are reviewed,so as to provide evidence for the prevention and treatment of fluoride-induced male reproductive damage.

关 键 词：氟 雄性 生殖毒性 毒理学 

分 类 号：R155[医药卫生—营养与食品卫生学]