功能性便秘与焦虑抑郁共病的研究进展  

Research progress of functional constipation and anxiety and depression comorbidity

作　　者：王玲 樊文彬 倪嘉淳 蔡增进 Wang Ling;Fan Wenbin;Ni Jiachun;Cai Zengjin(Department of Proctology,Yongchuan Hospital of Traditional Chinese Medicine,Chongqing Medical University,Chongqing 402160,China;School of Nursing,Chongqing College of Traditional Chinese Medicine,Chongqing 402760,China;Department of Coloproctology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,ShanghaiUniversity of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]重庆医科大学附属永川中医院肛肠科,402160 [2]重庆中医药学院护理学院,402760 [3]上海中医药大学附属岳阳中西医结合医院肛肠科,200437

出　　处：《中华结直肠疾病电子杂志》2024年第5期411-416,共6页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：重庆市教育委员会科学技术研究项目(No.KJQN202315143)。

摘　　要：功能性便秘是临床常见疾病,长期便秘的患者普遍存在焦虑和抑郁倾向,而针对焦虑抑郁障碍的药物治疗可能进一步加剧便秘问题,使得二者共病陷入恶性循环。因此,如何妥善处理功能性便秘与焦虑抑郁共病是临床亟需解决的重要问题。了解此类共病的发病互作机制及选择合适的精神心理评估问卷对患者进行精神心理评估是治疗的关键。本文从神经系统、脑肠肽分泌异常、肠道微生物、药物、肠道免疫机制方面探讨功能性便秘与焦虑抑郁共病发病互作机制,并回顾了相关精神心理评估问卷,旨在分析其发病因素,探讨心理评估对治疗便秘的重要性,以期为功能性便秘与焦虑抑郁共病的诊疗提供参考。Functional constipation is a common clinical condition,with long-term sufferers frequently exhibiting tendencies toward anxiety and depression.Medication targeting anxiety and depression may exacerbate constipation,creating a vicious cycle of comorbidity.Therefore,effectively managing the coexistence of functional constipation and anxiety-depression is a crucial clinical challenge.Understanding the interaction mechanisms of such comorbidities and selecting appropriate psychosocial assessment questionnaires are key to treatment.This article explores the interaction mechanisms of functional constipation with anxiety and depression from the perspectives of the nervous system,abnormal brain-gut peptide secretion,gut microbiota,drug effects,and intestinal immune mechanisms.It also reviews related psychosocial assessment questionnaires,aiming to analyze the factors contributing to these conditions and to emphasize the importance of psychological assessment in treating constipation,providing a reference for the diagnosis and treatment of comorbid functional constipation and anxietydepression.

关 键 词：功能性便秘 焦虑 抑郁 共病 

分 类 号：R574[医药卫生—消化系统]