炎症性肠病中血小板异常的研究进展  

Research Progress of Platelet Abnormalities in Inflammatory Bowel Disease

作　　者：李海晨 张哲伟 任政宇 陈羽玲 厉英超[1] LI Haichen;ZHANG Zhewei;REN Zhengyu;CHEN Yuling;LI Yingchao(Department of Gastroenterology,the First Affiliated Hospital of Xi′an Jiaotong University,Xi′an,710061;Department of PET-CT,the First Affiliated Hospital of Xi′an Jiaotong University,Xi′an,710061)

机构地区：[1]西安交通大学第一附属医院消化内科,710061 [2]西安交通大学第一附属医院PET-CT室,710061

出　　处：《胃肠病学》2024年第4期242-247,共6页Chinese Journal of Gastroenterology

摘　　要：血小板是止血和凝血的关键因素,近年来其参与炎症反应和免疫反应的潜能受到广泛关注。越来越多的研究表明,炎症性肠病的组织损伤并不仅仅是免疫应答失调的结果,还涉及其他多种细胞系统的积极参与,血小板可能在肠道黏膜炎症和免疫中发挥重要作用。本文就炎症性肠病中的血小板异常及其可能发生机制,以及血小板作为炎症性肠病特异性治疗靶点的前景作一综述。Platelet is the key factor in hemostasis and coagulation,its potential in inflammatory response and immune response has been widely concerned in recent years.A growing number of studies indicate that tissue damage in inflammatory bowel disease is not only the result of dysregulated immune response,but also the active participation of various other cellular systems,and platelet might play an important role in intestinal mucosal inflammation and immunity.This article reviewed the abnormal changes and possible mechanisms of platelet in inflammatory bowel disease,and the prospects of platelet as a specific treatment target for inflammatory bowel disease.

关 键 词：炎症性肠病 结肠炎 溃疡性 CROHN病 血小板 治疗 

分 类 号：R574[医药卫生—消化系统]