数字干预技术对抑郁症患者复燃复发影响的Meta分析  

The effects of digital technology interventions on relapse or recurrent in patients with major depressive disorder:a Meta-analysis

作　　者：李睿楠 冯子昭 肖乐[1,2] 冯媛[1,2] 张玲[1,2] 周晶晶[1,2] 王刚[1,2] 齐涵 Li Ruinan;Feng Zizhao;Xiao Le;Feng Yuan;Zhang Ling;Zhou Jingjing;Wang Gang;Qi Han(Beijing Key Laboratory of Mental Disorders,National Clinical Research Center for Mental Disorders&National Center for Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京安定医院国家精神疾病医学中心、国家精神心理疾病临床医学研究中心、精神疾病诊断与治疗北京市重点实验室,100088 [2]首都医科大学人脑保护高精尖创新中心,100069

出　　处：《神经疾病与精神卫生》2024年第11期782-788,共7页Journal of Neuroscience and Mental Health

基　　金：北京市医院管理中心青年人才培养“青苗”计划(QML20231905);北京市属医院科研培育计划(PX2024070);北京安定医院萌芽科创基金[2024年第(20)号]。

摘　　要：目的评价数字干预技术对抑郁症患者复燃复发的影响。方法2名研究者独立在PubMed、Cochrane Library、Embase、PsycINFO、中国知网、万方数据库和中国生物医学文献数据库检索数字干预技术对抑郁症患者复燃复发影响的随机对照试验研究,检索时间从建库到2024年5月26日。采用修改后的JADAD量表对纳入的文献质量进行评价,采用GRADE分级系统评价证据质量,使用Stata MP 18.0软件的“metan”程序包进行数字干预技术对抑郁症患者复燃复发影响的Meta分析。结果共纳入7项随机对照试验研究,1436例患者。Meta分析结果显示,与常规治疗组相比,数字干预技术可以有效降低抑郁症患者复燃复发的比例(RR=0.63,95%CI=0.47~0.83,I2=68.4%,P=0.004)。亚组分析发现不同的数字干预技术种类、实施周期和实施地区可能是异质性的来源,其中数字化认知疗法和康复训练程式可以有效降低抑郁症患者复燃复发的比例。结论数字干预技术可以有效改善抑郁症患者的复燃复发。Objective To evaluate the effects of digital technology interventions on the relapse or recurrent in patients with major depressive disorder.Methods Two researchers independently searched PubMed,Cochrane Library,Embase,PsycINFO,China National Knowledge Infrastructure(CNKI),Wanfang and China Biology Medicine(CBM)databases for randomized controlled trials on the effect of digital technology interventions on the relapse or recurrent in patients with major depressive disorder from inception to May 26th,2024.Revised-JADAD scale was used to evaluate the quality of included studies.The GRADE guideline was performed to rate the quality of evidence.The meta-analysis of the effects of digital techrology interventions on relapse or recurent in patients with major depressive disorder was conducted with the"metan"package of Stata MP 18.0 software.Results Seven randomized controlled trials and 1436 patients were finally included in the data synthesis.The results showed that compared with the control group,digital technology interventions could effectively reduce the proportions of relapses or recurrent in patients with major depressive disorder(RR=0.63,95%CI=0.47-0.83,I2=68.4%,P=0.004).Subgroup analysis found that different types of digital technologies,study duration and study sites could be the source of heterogeneity.Of them,internet-delivered cognitive behavior therapy and rehabilitation training program had better effects in reducing the proportions of relapses and recurrent in patients with major depressive disorder.Conclusions Digital technology interventions had benefits in improving the relapse and recurrent in patients with major depressive disorder.

关 键 词：数字干预技术 抑郁症 复发 复燃 META分析 

分 类 号：R749.4[医药卫生—神经病学与精神病学]