帕金森病患者腔隙性脑梗死患病率的Meta分析  

Prevalence of lacunar infarction in patients with Parkinson disease:a Meta-analysis

作　　者：刘颖 张楚天 夏金言 李珣 林凡[1] 张宏伟[2] 蔡晶 Liu Ying;Zhang Chutian;Xia Jinyan;Li Xun;Lin Fan;Zhang Hongwei;Cai Jing(School of Traditional Chinese and Western Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;School of Traditional Chinese Medicine,the Chinese University of Hong Kong,Hong Kong 999077,China;Department of Geriatrics,the Third People's Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China)

机构地区：[1]福建中医药大学中西医结合学院,福州350122 [2]香港中文大学中医学院,中国香港999077 [3]福建中医药大学附属第三人民医院老年病科,福州350122

出　　处：《神经疾病与精神卫生》2024年第11期789-796,共8页Journal of Neuroscience and Mental Health

基　　金：国家自然科学基金(82074507);福建省自然科学基金(2023J02023);福建省2022年省级临床重点专科建设项目(闽卫医政函[2022]884号)。

摘　　要：目的系统评价帕金森病患者腔隙性脑梗死的患病率。方法计算机检索PubMed、Web of Science、The Cochrane Library、Embase、中国知网、万方数据库、维普网和中国生物医学文献数据库,搜索有关腔隙性脑梗死与帕金森病相关的研究,检索时限均为建库至2024年9月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 17.0软件进行帕金森病患者腔隙性脑梗死患病率的Meta分析。结果共纳入12篇文献,涉及1335例帕金森病患者。Meta分析结果显示,帕金森病患者的腔隙性脑梗死总患病率为26.2%(95%CI:17.9%~34.6%)。亚组分析结果显示:3.0T MRI诊断的腔隙性脑梗死患病率(28.1%)高于1.5T MRI(20.9%);按照国际运动障碍协会标准诊断的帕金森病腔隙性脑梗死患病率(33.4%)高于英国脑库标准(20.8%);中国帕金森病患者腔隙性脑梗死患病率(32.6%)高于日本和韩国(13.3%);2021—2023年帕金森病患者腔隙性脑梗死患病率(28.3%)高于2015—2020年(24.2%);队列研究帕金森病患者腔隙性脑梗死患病率(47.2%)高于横断面研究(31.6%)和病例对照研究(11.6%)的结果。结论帕金森病患者腔隙性脑梗死患病率较高,故应重视帕金森病患者并发脑小血管病变的诊疗。Objective To systematically review the prevalence of lacunar infarction in Parkinson disease patients.Methods The research on lacunar infarction and Parkinson disease was electronically retrieved in PubMed,Web of Science,The Cochrane Library,Embase,CNKI,WanFang Data,VIP,and China Biomedical Database.The search period was from the establishment of the database to September 2024.After independently screening literature,extracting data,and evaluating the risk of bias for inclusion in the study by two researchers,Stata 17.0 was used to conduct a Meta-analysis of the prevalence of lacunar infarction in Parkinson disease patients.Results A total of 12 articles were included,involving 1335 Parkinson disease patients.Meta-analysis showed that the overall prevalence of lacunar infarction in Parkinson disease patients was 26.2%[95%CI(17.9%,34.6%)].Subgroup analysis showed that the prevalence of lacunar infarction diagnosed by 3.0T MRI(28.1%)was higher than that diagnosed by 1.5T MRI(20.9%).The prevalence of lacunar infarction diagnosed according to the International Parkinson and Movement Disorder Society criteria(33.4%)was higher than the UK Brain Banks criteria(20.8%).The prevalence of lacunar infarction in Parkinson disease in China(32.6%)was higher than that in Japan and South Korea(13.3%).The prevalence of lacunar infarction in Parkinson disease patients from 2021 to 2023(28.3%)was higher than that from 2015 to 2020(24.2%).The prevalence of lacunar infarction in Parkinson disease patients in cohort studies(47.2%)was higher than that in cross-sectional studies(31.6%)and case-control studies(11.6%).Conclusions The prevalence of lacunar infarction is relatively high in Parkinson disease patients,so the diagnosis and treatment of cerebral small vessel disease in Parkinson disease patients should be taken seriously.

关 键 词：帕金森病 腔隙性脑梗死 患病率 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R742.5[医药卫生—临床医学]