RELN基因启动子区甲基化及其多态性改变与精神分裂症的相关性研究进展  

Research progress on correlation between promoter methylation and polymorphism of RELN gene and schizophrenia

作　　者：王齐 Wang Qi(Department of Clinical Laboratory,Tianjin Children's Hospital&Children's Hospital,Tianjin University,Tianjin 300000,China)

机构地区：[1]天津市儿童医院(天津大学儿童医院)检验科,300000

出　　处：《神经疾病与精神卫生》2024年第11期820-825,共6页Journal of Neuroscience and Mental Health

摘　　要：精神分裂症的发病机制至今尚未明确。研究表明,精神分裂症的发生、发展与大脑神经系统功能异常相关。RELN编码的Reelin可通过分子信号通路调节神经元的正确定位和突触的可塑性参与精神分裂症的发生、发展。本文综述了RELN基因和Reelin蛋白的结构及在神经系统中的作用以及RELN基因与精神分裂症的关系,以期为深入研究精神分裂症的发病机制及临床治疗提供更多思路。The pathogenesis of schizophrenia is still unclear.Studies have shown that the occurrence and progress of schizophrenia are related to abnormal brain and nervous system function.RELN encoded Reelin protein can participate in the occurrence and progress of schizophrenia by regulating the correct localization of neurons and synaptic plasticity through molecular signaling pathways.This paper reviews the structure and role of RELN gene and Reelin protein in the nervous system,as well as the relationship between RELN gene and schizophrenia,providing ideas for further research on the pathogenesis and clinical treatment of schizophrenia.

关 键 词：精神分裂症 基因多态性 RELN Reelin蛋白 启动子区甲基化 综述 

分 类 号：R749.3[医药卫生—神经病学与精神病学]