Evaluating the effect of moisturizers containing endogenous lipids on skin barrier properties  

作　　者：Yucong Wang Shuting Li Yunfei Ai Stephen Lynch Nada Baalbaki Xianghua Zhang Xiaofeng He Xiaoqing Huang Andrew Steel Kungchi Hsu Hequn Wang 

机构地区：[1]L'Oréal China Research&Innovation,Shanghai 201206,China [2]L’Oréal Dermatological Beauty China,CeraVe,Shanghai 200040,China [3]L’Oréal USA Research&Innovation,Clark 07066,USA [4]CeraVe,New York 10001,USA [5]L'Oréal South Korea Research&Innovation,Seoul 06164,Korea

出　　处：《Journal of Dermatologic Science and Cosmetic Technology》2024年第3期14-19,共6页皮肤科学与化妆品技术期刊（英文）

摘　　要：Lipids in stratum corneum are largely responsible for skin barrier function.There have been numerous studies on skin barrier repairing and moisturizing effects of products containing occlusives,emollients and humectants.However,currently there are few studies systematically evaluating effect of moisturizers containing endogenous lipids on skin barrier properties.The objective of this study was to study the effect of products containing endogenous lipids on various barrier-related indicators.A total 89 subjects with dry skin were enrolled.To evaluate the effect of the test products on skin barrier function and hydration after 28 days of use on the face,this study combined clinical assessments of skin condition(skin redness,global appearance of dry line,skin roughness and radiance),instrumental assessments(transepidermal water loss,skin hydration and scaliness)and photo tracking(VISIA-CR,VC20 and 3D in-vivo Reflectance Confocal Microscope).Adverse reactions were also assessed.All test products showed significant improvement in all the attributes assessed by both clinical assessments and instrumental assessments after 28 days of treatment.In addition,the products containing skinidentical ceramides and niacinamide show improvement on TEWL and skin hydration.Two products containing exogenous lipids can improve skin hydration and barrier function which have demonstrated efficacy in improving dry skin condition.

关 键 词：SKIN BARRIER CERAMIDE 

分 类 号：R751[医药卫生—皮肤病学与性病学]