DCE-MRI参数与子宫内膜癌分化程度及组织VEGF、P53表达的关系  

Effect of Kuntai Gel Combined with Fenmutong on Sex Hormone Levels and Uterine Artery Hemodynamic Parameters in Patients with Ovarian Reserve Dysfunction

作　　者：于坤 周衍德 何磊磊 YU Kun;ZHOU Yande;HE Leilei(Obstetrics and Gynecology Department of Suzhou University Affiliated Fourth Hospital(Suzhou Dushu Lake Hospital),Suzhou,Jiangsu Province 215000,P.R.China)

机构地区：[1]苏州大学附属第四医院(苏州市独墅湖医院)妇产科,苏州215000 [2]浙江省宁波市第二医院内分泌科,315010

出　　处：《临床放射学杂志》2024年第12期2128-2132,共5页Journal of Clinical Radiology

基　　金：浙江省医药卫生科技计划项目(编号:2019RC078、2020KY833);浙江省自然科学基金项目(编号:LQ20H070002)。

摘　　要：目的 探讨动态增强磁共振成像(DCE-MRI)参数与子宫内膜癌(EC)分化程度及组织血管内皮生长因子(VEGF)、P53表达的关系。方法 回顾性分析经手术病理证实的130例EC患者的临床资料,对比不同分化程度EC患者DCE-MRI参数。统计EC组织VEGF、P53蛋白表达情况,并分析其与患者临床病理的关系。对比不同VEGF、P53表达EC患者DCE-MRI参数。Spearman分析EC患者DCE-MRI参数与分化程度、VEGF及P53的相关性。结果 不同分化程度EC患者速率常数(K_(ep))、容积转运常数(K^(trans))、细胞外间隙对比剂容积分数(V_(e))值对比,差异有统计学意义(P<0.05);低分化和中分化K_(ep)值、K^(trans)值及V_(e)值均>高分化(P<0.05);低分化K_(ep)值、K^(trans)值及V_(e)值均>中分化(P<0.05)。EC组织中VEGF阳性表达率为80.77%,P53阳性表达率为63.85%。临床分期Ⅲ~Ⅳ期、肌层浸润>1/2、淋巴结转移、低分化EC组织VEGF阳性表达率和P53阳性表达率高于临床分期Ⅰ~Ⅱ期、肌层浸润≤1/2、无淋巴结转移、中/高分化(P<0.05)。VEGF阳性K_(ep)值、K^(trans)值及V_(e)值>VEGF阴性(P<0.05);P53阳性K_(ep)值、K^(trans)值及V_(e)值>P53阴性(P<0.05)。EC患者K_(ep)值、K^(trans)值及V_(e)值与分化程度呈负相关(P<0.05);EC患者K_(ep)值、K^(trans)值及V_(e)值与VEGF、P53呈正相关(P<0.05)。结论 DCE-MRI参数与EC分化程度及组织VEGF、P53表达均相关。Objective To explore the relationship between the parameters of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)and the differentiation degree of endometrial carcinoma(EC)and the expression of vascular endothelial growth factor(VEGF)and P53.Methods The clinical data of 130 patients with EC admitted and confirmed by surgery and pathology were analyzed retrospectively.DCE-MRI parameters of EC patients with different differentiation degrees were compared.The expression of VEGF and P53 protein in EC tissue was quantified,and the relationship between them and the clinical pathology of patients was analyzed.DCE-MRI parameters of EC patients with different VEGF and P53 expressions were compared.Spearman's analysis was used the correlation between DCE-MRI parameters and differentiation degree,VEGF and P53 in EC patients.Results There were statistically significant differences in rate constant(K_(ep)),volume transport constant(K^(trans))and volume fraction of contrast agent in extracellular space(V_(e))among EC patients with different differentiation degrees(P<0.05).The K_(ep),K^(trans) and V_(e) value of low differentiation and middle differentiation were higher than those of high differentiation(P<0.05).The K_(ep),K^(trans) and V_(e) value of low differentiation were higher than those of middle differentiation(P<0.05).The positive expression rates of VEGF and P53 in EC tissues were 80.77%and 63.85%,respectively.Clinical stagesⅢ-Ⅳ,myometrial invasion>1/2,lymph node metastasis,the positive expression rates of VEGF and P53 in poorly differentiated EC tissues were higher than those in clinical stagesⅠ-Ⅱ,myometrial invasion≤1/2,no lymph node metastasis and moderate/high differentiation(P<0.05).The K_(ep),K^(trans) and Ve value of VEGF positive were higher than those of VEGF negative(P<0.05).The K_(ep),K^(trans) and V_(e) value of P53 positive were higher than those of P53 negative(P<0.05).The K_(ep),K^(trans) and V_(e) value of EC patients were negatively correlated with the degree of differentiation(P

关 键 词：子宫内膜癌 分化程度 血管内皮生长因子 P53 动态增强磁共振成像 

分 类 号：R737.33[医药卫生—肿瘤] R445.2[医药卫生—临床医学]