基于CTU三维模式下肿瘤体积对非肌层浸润性膀胱癌复发的预测模型  

Prediction value of tumor volume for recurrence of non-muscle invasive bladder cance based on three-dimensional CTU model

作　　者：徐忠乐 席俊华[1] 张艳斌[1] Xu Zhonge;Xi Junhua;Zhang Yanbin(Department of Urology,the Second People's Hospital of Hefei,Hefei Hospital Affiliated to Anhui Medical Univer-sity,Hefei 230011,China)

机构地区：[1]合肥市第二人民医院泌尿外科(安徽医科大学附属合肥医院),合肥230011

出　　处：《微创泌尿外科杂志》2024年第5期324-328,共5页Journal of Minimally Invasive Urology

基　　金：合肥市卫生健康委2020年度应用医学重点研究项目(Hwk2020zd0011)。

摘　　要：目的:探讨CT尿路造影(CTU)三维模式下肿瘤体积对非肌层浸润性膀胱癌复发的预测价值。方法:回顾性分析2016年1月至2020年3月124例行经尿道膀胱肿瘤电切术患者的临床资料。所有患者术前均完成CTU,在CTU构建的三维模式中勾画出感兴趣区域,测得肿瘤的长、宽、高,利用公式计算出肿瘤有效体积(TV)。根据术后2年随访的结果分为复发组(n=25)和非复发组(n=99),采用单因素分析比较两组临床资料的差异,并对有意义的因素行非条件Logistic多因素回归分析。采用受试者工作特征(ROC)曲线计算独立预测因素曲线下面积(AUC),并分析最佳临界值及对应的灵敏度和特异性。结果:124例患者术后3个月、2年复发率分别为4.8%(6/124)、20.1%(25/124)。复发组的肿瘤体积[2.9(1.8,4.7)cm^(3)]和肿瘤分级高级别比例(40%)均高于非复发组[分别为1.4(0.6,2.3)cm^(3)、20%],差异均有统计学意义(P值分别为0.04、0.03)。结论:肿瘤体积可以作为非肌层浸润性膀胱癌术后复发的独立预测因素。Objective:To investigate the predictive value of tumor volume in CT urography(CTU)three-di-mensional mode for recurrence of non-muscle invasive bladder cancer.Methods:The data of 124 patients who under-went transurethral resection of bladder tumor from January 2016 to March 2020 were retrospectively analyzed.All of the patients received CTU,the region of interest was delineated in the three-dimensional mode constructed by CTU,the length,width and height of the tumor were measured,and the effective tumor volume(TV)was calculated using the formula.According to the 2-year follow-up results,they were divided into recurrence group(n=25)and non-re-currence group(n=99).Univariate analysis was used to compare the differences in clinical data between the two groups,and unconditional Logistic regression analysis was performed for significant factors.The receiver operating characteristic(ROC)curve was used to calculate the area under the curve(AUC)of independent predictors,and the optimal cut-off value and corresponding sensitivity and specificity were analyzed.Results:In 124 patients,the recur-rence rates of 3 months and 2 years after operation were 4.8%(6/124)and 20.1%(25/124),respectively.The tumor volume[2.9(1.8,4.7)cm^(3)]and proportion of high-grade tumors(40%)in the recurrence group were higher than those in the non-recurrence group[1.4(0.6,2.3)cm^(3),20%],the differences were statistically significant(P=0.04,P=0.03).Conclusion:Tumor volume can be used as an independent predictor of postoperative tumor recurrence.

关 键 词：非肌层浸润性膀胱癌 肿瘤体积 复发 预测因素 三维模式 

分 类 号：R737.14[医药卫生—肿瘤]