性类固醇激素与近视之间的因果关系:一项孟德尔随机化研究  

Causal relationship between sex steroid hormones and myopia:a Mendelian randomization study

作　　者：李宝花 亢泽峰[1] 张明明[1] 侯昕玥 王健全 李丹玉 刘梦雨 师宜鹏 LI Baohua;KANG Zefeng;ZHANG Mingming;HOU Xinyue;WANG Jianquan;LI Danyu;LIU Mengyu;SHI Yipeng(China Academy of Chinese Medical Sciences Eye Hospital,Beijing 100040,China)

机构地区：[1]中国中医科学院眼科医院,北京市100040

出　　处：《眼科新进展》2024年第12期961-966,共6页Recent Advances in Ophthalmology

基　　金：国家重点研发计划“揭榜挂帅”重点专项(编号:2022YFC3502500,2022YFC3502505);国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者项目[编号:国中医药人教发(2018)284号];中央高水平中医医院“揭榜挂帅”专项(编号:GSP4-01);中国中医科学院眼科医院中央高水平中医医院项目(编号:GSP5-90)。

摘　　要：目的利用孟德尔随机化(MR)法分析血清性类固醇激素水平与近视之间的因果关系。方法按照性别分类的性激素遗传工具是来自英国生物银行财团关于性激素结合球蛋白(SHBG)、总睾酮(TT)、生物可用睾酮(BT)和雌二醇(E2)的全基因组关联研究(GWAS)公开汇总统计数据。近视的GWAS汇总统计数据来自芬兰财团R10发布的公开数据。所有数据于2024年4月18日至31日从相应数据库中下载并进行分析。所有MR的结果分析以逆方差加权(IVW)方法为主。结果欧洲人群中较高的血清SHBG水平增加女性近视发生的风险(IVW,OR=1.152,95%CI:1.014~1.308,P=0.029);而低水平血清TT(IVW,OR=0.821,95%CI:0.697~0.967,P=0.018)和BT(IVW,OR=0.820,95%CI:0.691~0.972,P=0.022)水平增加女性近视发生的风险。男性血清SHBG、TT、BT水平与近视之间不存在因果关系。无论男女,其E2与近视之间不存在因果效应。敏感性分析支持本研究结果的稳定性。结论女性血清SHBG水平升高、TT和BT水平降低与近视风险增加有关,而在男性中未发现这种关联。E2与近视之间没有因果关系。Objective To analyze the causal relationship between serum sex steroid hormone levels and myopia with the Mendelian randomization(MR)methods.Methods Sex hormone genetic tools classified by sex were publicly available summarized statistical data from the Genome-wide association study(GWAS)of the UK Biobank Consortium on sex hormone-binding globulin(SHBG),total testosterone(TT),bioavailable testosterone(BT),and estradiol(E2).The GWAS summarized statistical data for myopia were obtained from publicly available data published by the FinnGen Consortium R10.All data were downloaded from April 18 to April 31,2024 from the corresponding databases and analyzed.All results from the MR study were mainly analyzed by inverse-variance weighting(IVW)method.Results The study showed that a higher serum SHBG level in European increased the risk of myopia development in women(IVW,OR=1.152,95%CI:1.014-1.308,P=0.029);low serum TT level(IVW,OR=0.821,95%CI:0.697-0.967,P=0.018)and serum BT level(IVW,OR=0.820,95%CI:0.691-0.972,P=0.022)increased the risk of myopia development in women.There was no causal relationship between serum SHBG,TT,and BT levels and myopia in men.There was no causal effect between E2 level and myopia in women and men.The stability of our findings was supported by sensitivity analysis.Conclusion Increased serum SHBG level and decreased serum TT and BT levels are associated with an increased risk of myopia in women,whereas no such association is found in men.There is no causal relationship between E2 and myopia.

关 键 词：孟德尔随机化 近视 性类固醇激素 性激素结合球蛋白 睾酮 雌二醇 

分 类 号：R778.1[医药卫生—眼科]