基于视网膜神经胶质血管单元损伤防治糖尿病视网膜病变的研究进展  

Progress in the prevention and treatment of diabetic retinopathy based on retinal neuroglial vascular unit injury

作　　者：蒋孟洋 李志林 吴泓樾 袁晓辉 段俊国[1] JIANG Mengyang;LI Zhilin;WU Hongyue;YUAN Xiaohui;DUAN Junguo(the Sichuan Key Laboratory of Ophthalmic Disease Prevention and Treatment and Visual Function Protection of Traditional Chinese Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;Yinhai Ophthalmic Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610036,Sichuan Province,China)

机构地区：[1]成都中医药大学中医药眼病防治与视功能保护四川省重点实验室,四川省成都市610075 [2]成都中医大学银海眼科医院,四川省成都市610036

出　　处：《眼科新进展》2024年第12期995-998,1004,共5页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助项目(编号:82074335)。

摘　　要：糖尿病视网膜病变(DR)是糖尿病常见的眼部慢性微血管并发症,是40岁以上人群中排在首位的致盲性眼底病。当前研究表明神经胶质血管单元(NGVU)损伤会引起DR多种特征性眼底改变,包括渗出、棉绒斑、微血管瘤、出血、新生血管形成等。近年来相关研究证实DR患者视网膜NGVU损伤出现在视网膜微血管病变之前,且与视功能受损密切相关,故NGVU未来有望成为防治早期DR的潜在治疗靶点。本文对NGVU与DR治疗关系的研究进展进行了综述,以期为预防及干预早期DR进展提供新的研究方向。Diabetic retinopathy(DR)is a common ocular chronic microvascular complication of diabetes mellitus and is the leading blinding fundus disease in people over 40 years of age.Current studies have shown that neuroglial vascular unit(NGVU)injury causes a variety of characteristic fundus changes in DR patients,including exudation,cotton wool spots,microangioma,bleeding,and neovascularization.Recent studies have confirmed that retinal NGVU injury in DR patients occurs before retinal microangiopathy and is closely related to impaired visual function,so NGVU is expected to be a potential therapeutic target for the prevention and treatment of early DR in the future.In this paper,the research progress on the relationship between NGVU and DR treatment is reviewed,intending to provide new research directions for the prevention and intervention of early DR progression.

关 键 词：糖尿病视网膜病变 神经胶质血管单元损伤 靶向治疗 炎症因子 

分 类 号：R774[医药卫生—眼科]