血清NFL、GFAP水平与帕金森病患者焦虑抑郁的相关性研究  

Association of the serum levels of neurofilament light chain and glial fibrillary acidic protein with anxiety and depression in patients with Parkinson disease

作　　者：李杨丹钰 李富佳 刘旭 徐传英 崔桂云 LI Yangdanyu;LI Fujia;LIU Xu(The Affiliated Hospital of Xuzhou Medical University,Xuzhou 221000,China)

机构地区：[1]徐州医科大学附属医院,江苏徐州221000

出　　处：《中风与神经疾病杂志》2024年第11期982-987,共6页Journal of Apoplexy and Nervous Diseases

基　　金：江苏省重点研发计划(社会发展)项目(BE2021630);徐州市卫生健康委员会医学科技创新项目(XWKYHT20220158);徐州医科大学揭榜挂帅攻关项目(JBGS202203)。

摘　　要：目的探究血清神经丝轻链(NFL)和胶质纤维酸性蛋白(GFAP)与帕金森病(PD)伴焦虑抑郁的相关性。方法本研究共选取96例PD患者和38例健康对照,并根据汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁评定量表(HAMD)评估PD患者焦虑抑郁情况并进行疾病分组。运用超灵敏单分子阵列(Simoa)技术定量检测血清中NFL和GFAP含量。比较不同组间的NFL及GFAP水平,并通过Spearman相关性分析及Logistic回归分析探究NFL、GFAP与PD焦虑抑郁的相关性,最后通过ROC曲线确定GFAP水平对于PD伴抑郁的诊断价值。结果与健康对照组相比,PD伴或不伴焦虑抑郁患者中的NFL水平升高(P<0.001);与PD不伴抑郁或焦虑的患者相比,PD伴抑郁或焦虑患者中的GFAP水平升高(P<0.05)。PD患者血清GFAP水平与焦虑抑郁程度呈正相关(r=0.271,P=0.008;r=0.302,P=0.003)。调整混杂因素后,Logistic回归分析显示GFAP仍是PD是否伴发抑郁的独立危险因素(P=0.028)。ROC曲线显示GFAP诊断PD伴抑郁的曲线下面积为0.660。结论血清GFAP水平与PD焦虑抑郁有关,并且是PD伴抑郁的独立危险因素。Objective To investigate the association of serum neurofilament light chain(NFL)and glial fibrillary acidic protein(GFAP)with Parkinson disease(PD)with anxiety and depression.Methods A total of 96 PD patients and 38 healthy controls were enrolled in this study.Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)were used to evaluate anxiety and depression in the PD patients,and the patients were divided into groups based on their diseases.Ultrasensitive single molecule array(Simoa)was used to quantitatively measure the serum levels of NFL and GFAP.The levels of NFL and GFAP were compared between groups;Spearman correlation analysis and logistic re⁃gression analysis were used to investigate the association of NFL and GFAP with anxiety and depression in PD patients;the receiver operating characteristic(ROC)curve was used to access the value of GFAP level in the diagnosis of PD with de⁃pression.Results Compared with the healthy control group,the PD patients with or without anxiety and depression had a significant increase in the level of NFL(P<0.001),and compared with the PD patients without depression or anxiety,the PD patients with depression or anxiety had a significant increase in the level of GFAP(P<0.05).In the PD patients,the serum level of GFAP was positively correlated with the degree of anxiety(r=0.271,P=0.008)and depression(r=0.302,P=0.003).After adjustment for confounding factors,the logistic regression analysis showed that GFAP remained an inde⁃pendent risk factor for depression in PD patients(P=0.028).The ROC curve analysis showed that GFAP had an area un⁃der the ROC curve of 0.660 in the diagnosis of PD with depression.Conclusion Serum GFAP level is associated with anxiety and depression in PD and is an independent risk factor for PD with depression.

关 键 词：帕金森病 神经丝轻链 胶质纤维酸性蛋白 焦虑 抑郁 

分 类 号：R742.5[医药卫生—神经病学与精神病学]